Evidence map›Paper›PMID 30833001›Full record

ReviewHematology/oncology clinics of North America2019

Prognostic and Predictive Immunohistochemistry-Based Biomarkers in Cancer and Immunotherapy.

Emanuelle M Rizk, Robyn D Gartrell, Luke W Barker, Camden L Esancy, Grace G Finkel, Darius D Bordbar, Yvonne M Saenger

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Tumor biomarkers for diagnosis, prognosis and targeted therapy.Signal transduction and targeted therapy · 2024
    Review
  8. Clinical Proteomics for Solid Organ Tissues.Molecular & cellular proteomics : MCP · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuelle M RizkDepartment of Medicine, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Robyn D GartrellDepartment of Medicine, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Luke W BarkerCollege of Physicians and Surgeons, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Camden L EsancyDepartment of Medicine, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Grace G FinkelCollege of Physicians and Surgeons, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Darius D BordbarCollege of Physicians and Surgeons, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA.
Yvonne M SaengerDepartment of Medicine, Columbia University Irving Medical Center, 650 West 168th Street, Black Building 8-816, New York, NY 10032, USA. Electronic address: yms4@cumc.columbia.edu.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
SHORT-TERM TRAINING: STUDENTS IN PROFESSIONAL SCHOOLST35HL007616 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI RUDOLPH L LEIBEL, Markus Y Mapara · 1985 to 2026
$4.4M
Ph1 Study of T-Vec given endoscopically for advanced pancreatic cancer IN 17248 (11/21/2016)R01FD006108 · FDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SAENGER, YVONNE MARGARET · 2018 to 2020
$750k
A prognostic mRNA immune signature for resected stage II-III melanomaUH2CA218149 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KROLEWSKI, JOHN J., SAENGER, YVONNE MARGARET · 2019 to 2020
$365k
FDA HHS R01 FD006108NCATS NIH HHS TL1 TR001875NCATS NIH HHS UL1 TR001873NCI NIH HHS UH2 CA218149NHLBI NIH HHS T35 HL007616
6 · The paper itself

Abstract

Immunotherapy has drastically improved the prognosis of many patients with cancer, but it can also lead to severe immune-related adverse events. Biomarkers, which are molecular markers that indicate a patient's disease outcome or a patient's response to treatment, are therefore crucial to helping clinicians weigh the potential benefits of immunotherapy against its potential toxicities. Immunohistochemistry (IHC) has thus far been a powerful technique for discovery and use of biomarkers such as CD8

Indexed as

Biomarkers, TumorImmunotherapyNeoplasmsCD8-Positive T-LymphocytesHumansImmunohistochemistryLymphocytes, Tumor-InfiltratingPrognosisBiomarkers, TumorCheckpoint inhibitionImmunohistochemistryImmunotherapyPredictive and prognostic biomarkers

Identifiers

PMID30833001
PMCPMC6497069

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.