Evidence map›Paper›PMID 30832653›Full record

ArticleBMC veterinary research2019

Effects of divergent selection upon adrenocortical activity on immune traits in pig.

Julie Hervé, Elena Terenina, Karine Haurogné, Elodie Bacou, Elizaveta Kulikova, Marie Allard, Yvon Billon, Jean-Marie Bach, Pierre Mormède, Blandine Lieubeau

Abstract read
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In one paragraph

Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie HervéIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France. julie.herve@oniris-nantes.fr.ORCID http://orcid.org/0000-0001-9735-5518
Elena TereninaGenPhySE, Université de Toulouse, INRA, INPT, ENVT, F-31326, Castanet-Tolosan, France. elena.mormede@inra.fr.
Karine HaurognéIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.
Elodie BacouIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.
Elizaveta KulikovaFederal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation, 630090.
Marie AllardIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.
Yvon BillonGenESI, INRA, Le Magneraud, F-17700, Saint-Pierre-d'Amilly, France.
Jean-Marie BachIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.
Pierre MormèdeGenPhySE, Université de Toulouse, INRA, INPT, ENVT, F-31326, Castanet-Tolosan, France.
Blandine LieubeauIECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.

Funding

ANR ANR-12-ADAP-0008
6 · The paper itself

Abstract

backgroundThe sustainability of farming and animal welfare requires the reconsideration of current selection schemes. In particular, implementation of new selection criteria related to animal health and welfare should help to produce more robust animals and to reduce anti-microbial use. The hypothalamo-pituitary-adrenocortical (HPA) axis plays a major role in metabolic regulation and adaptation processes and its activity is strongly influenced by genetic factors. A positive association between HPA axis activity and robustness was recently described. To explore whether selecting pigs upon HPA axis activity could increase their robustness, a divergent selection experiment was carried out in the Large White pig breed. This allowed the generation of low (HPA

resultsIn this study, we compared 23 hematologic and immune parameters of 6-week-old, HPA

conclusionsDivergent selection upon HPA axis activity modulated hematologic and immune parameters in 6-week-old pigs, which may confer an advantage to HPA

Indexed as

Selection, GeneticAdrenocorticotropic HormoneAnimalsBlood Cell CountFemaleHypothalamo-Hypophyseal SystemLipopolysaccharidesPituitary-Adrenal SystemSus scrofaTumor Necrosis Factor-alphaAdrenocorticotropic HormoneLipopolysaccharidesTumor Necrosis Factor-alphaCortisolGeneticsHypothalamic-pituitary-adrenocortical axisImmunityLPS challengeRobustnessStress

Identifiers

PMID30832653
PMCPMC6398250

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.