Evidence map›Paper›PMID 30832493›Full record

ArticleCell transplantation2019

Repetitive Transcranial Magnetic Stimulation Promotes Neural Stem Cell Proliferation and Differentiation after Intracerebral Hemorrhage in Mice.

Mengchu Cui, Hongfei Ge, Han Zeng, Hongxiang Yan, Le Zhang, Hua Feng, Yujie Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mengchu Cui1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Hongfei Ge1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Han Zeng2 College of Computer and Information Science, Southwest University, Chongqing, P. R. China.
Hongxiang Yan1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Le Zhang3 College of Computer Science, Sichuan University, Chengdu, P. R. China.
Hua Feng1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Yujie Chen1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.ORCID 0000-0002-9905-9138
Army Medical University · CNSichuan University · CNSouthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a physical treatment applied during recovery after intracerebral hemorrhage (ICH). With in vivo and in vitro assays, the present study sought to investigate how rTMS influences neural stem cells (NSCs) after ICH and the possible mechanism. Following a collagenase-induced ICH, adult male C57BL/6 J mice were subjected to rTMS treatment every 24 h for 5 days using the following parameters: frequency, 10 Hz; duration, 2 s; wait time, 5.5 s; 960 trains (500 µV/div, 5 ms/div, default setting). Brain water content and neurobehavioral score were assessed at days 1, 3, and 5 after ICH. The proliferation and differentiation of NSCs were observed using immunofluorescence staining for Nestin, Ki-67, DCX, and GFAP on day 3 after ICH, and rTMS treatment with the same parameters was applied to NSCs in vitro. We found that rTMS significantly reduced brain edema and alleviated neural functional deficits. The mice that underwent ICH recovered faster after rTMS treatment, with apparent proliferation and neuronal differentiation of NSCs and attenuation of glial differentiation and GFAP aggregation. Accordingly, proliferation and neuronal differentiation of isolated NSCs were promoted, while glial differentiation was reduced. In addition, microarray analysis, western blotting assays, and calcium imaging were applied to initially investigate the potential mechanism. Bioinformatics showed that the positive effect of rTMS on NSCs after ICH was largely related to the MAPK signaling pathway, which might be a potential hub signaling pathway under the complex effect exerted by rTMS. The results of the microarray data analysis also revealed that Ca

Indexed as

NeurogenesisTranscranial Magnetic StimulationAnimalsBrainCell ProliferationCells, CulturedCerebral HemorrhageDoublecortin ProteinMaleMiceMice, Inbred C57BLNeural Stem CellsWaterDcx protein, mouseDoublecortin ProteinWaterdifferentiationintracerebral hemorrhagemitogen-activated protein kinaseneural stem cellproliferationrepetitive transcranial magnetic stimulation

Identifiers

PMID30832493
PMCPMC7103604
OpenAlexW2920701096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.