ArticleInternational journal of environmental research and public health2019
Association between Periodontal Disease and Subsequent Sjögren's Syndrome: A Nationwide Population-Based Cohort Study.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The association of periodontal diseases and Sjogren's syndrome: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Transcriptomic Analysis Reveals C-C Motif Chemokine Receptor 1 as a Critical Pathogenic Hub Linking Sjögren's Syndrome and Periodontitis.Current issues in molecular biology · 2025Article
- Featured Immune Characteristics of Periodontitis and Primary Sjögren's Syndrome Revealed by Single-Cell Transcriptome Analyses.Journal of cellular and molecular medicine · 2025Article
- Response to the Letter to the Editor, "Sjögren's Disease Is Not a Clinical Risk Factor for Periodontitis".Journal of dental research · 2024Article
- Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study.BMC oral health · 2024Article
- Sjögren's Disease and Oral Health: A Genetic Instrumental Variable Analysis.Journal of dental research · 2024Observational
- Association between dry eye and periodontal disease in community-dwelling Japanese adults: data from the Uonoma cohort study.BMC oral health · 2024Article
- The Croatian Primary Sjögren's Disease Oral Health Study: Oral Status and Oral Health-Related Quality of Life.Journal of clinical medicine · 2023Article
- Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review.Journal of clinical medicine · 2023Review
- Association between Sjögren's Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Effects of periodontitis on cancer outcomes in the era of immunotherapy.The lancet. Healthy longevity · 2023Review
- Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren's syndrome and its relationship with disease severity.Central-European journal of immunology · 2023Article
- The Link between Stroke Risk and Orodental Status-A Comprehensive Review.Journal of clinical medicine · 2022Review
- Immunoglobulin Disorders and the Oral Cavity: A Narrative Review.Journal of clinical medicine · 2022Review
- Article
- Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data.BMJ open · 2021Article
- Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis.Journal of dental sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xerostomia (dry mouth) is the cardinal symptom of Sjögren's syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36⁻1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.