Evidence map›Paper›PMID 30832362›Full record

ArticleJournal of clinical medicine2019

Outcomes of Older Patients (≥60 years) with New-Onset Idiopathic Nephrotic Syndrome Receiving Immunosuppressive Regimen: A Multicentre Study of 116 Patients.

Eloïse Colliou, Alexandre Karras, Jean-Jacques Boffa, David Ribes, Cyril Garrouste, Moglie Le Quintrec, Eric Daugas, Antoine Huart, Didier Ducloux, Aurélie Hummel and 6 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eloïse ColliouDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. eloise.colliou@orange.fr.
Alexandre KarrasService de Néphrologie, Hôpital Européen-Georges Pompidou, Assistance Publique des Hôpitaux de Paris, 75015 Paris, France. Alexandre.karras@aphp.fr.
Jean-Jacques BoffaService de Néphrologie, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, 75020 Paris, France. jean-jacques.boffa@aphp.fr.
David RibesDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. ribes.d@chu-toulouse.fr.
Cyril GarrousteService de Néphrologie et Transplantation Rénale, Centre Hospitalier Universitaire de Clermont-Ferrand, 63000 Clermont-Ferrand, France. cgarrouste@chu-clermont-ferrand.fr.
Moglie Le QuintrecService de Néphrologie et Transplantation Rénale, Centre Hospitalier Universitaire de Montpellier, 34000 Montpellier, France. m-lequintrec-donnette@chu-montpellier.Fr.
Eric DaugasService de Néphrologie et Transplantation Rénale, Hôpital Bichat, Assistance Publique des Hôpitaux de Paris, 75018 Paris, France. eric.daugas@aphp.fr.ORCID 0000-0001-7256-7979
Antoine HuartDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. huart.a@chu-toulouse.Fr.
Didier DuclouxService de Néphrologie et Transplantation Rénale, Centre Hospitalier Universitaire de Besançon, 25000 Besançon, France. dducloux@chu-besancon.fr.
Aurélie HummelService de Néphrologie-Dialyse, Hôpital Necker, Assistance Publique des Hôpitaux de Paris, 75015 Paris, France. aurelie.hummel@aphp.fr.
Inès FerrandizDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. ines.ferrandiz01@gmail.com.
Nathalie DemoulinDépartement de Néphrologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1348 Louvain, Belgique. nathalie.demoulain@uclouvain.be.
Noémie Jourde-ChicheUniversité d'Aix-Marseille C2VN, INSERM 1263, INRA 1260; AP-HM, Centre de Néphrologie et Transplantation rénale, 13000 Marseille, France. noemie.jourde@ap-hm.fr.
Dominique ChauveauDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. chauveau.d@chu-toulouse.fr.
Vincent AudardService de Néphrologie et Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Mondor, Assistance Publique des Hôpitaux de Paris, Université Paris-Est Créteil (UPEC), INSERM U955, équipe 21, 94000 Créteil, France. vincent.audard@aphp.fr.ORCID 0000-0001-5343-2550
Stanislas FaguerDépartement de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France. stanislas.faguer@inserm.fr.ORCID 0000-0003-0553-0927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because of its rarity, renal presentation and outcomes of idiopathic nephrotic syndrome (INS; minimal changes disease or focal and segmental glomerulosclerosis) has poorly been described in elderly patients, precluding an individualized therapy procedure. Whether immunosuppressive regimens formerly designed in children and young adults are safe and efficient in elderly remains elusive. In a large multicentric retrospective study that included 116 patients with INS and onset ≥ 60 years of age, we showed that cumulative incidence of renal response was 95% after frontline therapy, with an age-dependent median time-to-response (60 days before 70 years of age at the onset vs. 120 days after;

Indexed as

focal segmental glomerulosclerosisinfectionminimal change diseaseolder patientsrituximab

Identifiers

PMID30832362
PMCPMC6463053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.