Evidence map›Paper›PMID 30832348›Full record

ArticleJournal of clinical medicine2019

Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue.

Young Jun Chai, Heejoon Chae, Kwangsoo Kim, Heonyi Lee, Seongmin Choi, Kyu Eun Lee, Sang Wan Kim

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Biosafety and health · 2026
    Article
  3. Review
  4. A Pilot Study ofBalkan journal of medical genetics : BJMG · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Young Jun ChaiDepartment of Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea. kevinjoon@naver.com.ORCID 0000-0001-8830-3433
Heejoon ChaeDivision of Computer Science, Sookmyung Women's University, Seoul 04310, Korea. heechae@sookmyung.ac.kr.ORCID 0000-0002-0960-5829
Kwangsoo KimDivision of Clinical Bioinformatics, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea. kksoo716@gmail.com.ORCID 0000-0002-4586-5062
Heonyi LeeDivision of Computer Science, Sookmyung Women's University, Seoul 04310, Korea. sophia5848@naver.com.
Seongmin ChoiDivision of Clinical Bioinformatics, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea. sm.alex.choi@gmail.com.ORCID 0000-0001-9722-1800
Kyu Eun LeeDepartment of Surgery, Seoul National University Hospital & College of Medicine, Seoul 03080, Korea. kyueunlee@snu.ac.kr.ORCID 0000-0002-2354-3599
Sang Wan KimDepartment of Internal Medicine, Seoul National University College of Medicine, and Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea. swkimmd@snu.ac.kr.ORCID 0000-0001-9561-9110
Seoul National University Hospital · KRSeoul National University · KRSookmyung Women's University · KR

Funding

Seoul National University Hospital 04-2017-0280
6 · The paper itself

Abstract

Parathyroid adenoma is the main cause of primary hyperparathyroidism, which is characterized by enlarged parathyroid glands and excessive parathyroid hormone secretion. Here, we performed transcriptome analysis, comparing parathyroid adenomas with normal parathyroid gland tissue. RNA extracted from ten parathyroid adenoma and five normal parathyroid samples was sequenced, and differentially expressed genes (DEGs) were identified using strict cut-off criteria. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using DEGs as the input, and protein-protein interaction (PPI) networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and visualized in Cytoscape. Among DEGs identified in parathyroid adenomas (

Indexed as

endoplasmic reticulumgene expression profilinggene ontologyhyperparathyroidismmessengerparathyroid adenomaparathyroid glandsparathyroid hormoneRNA

Identifiers

PMID30832348
PMCPMC6463127
OpenAlexW2918764962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.