Evidence map›Paper›PMID 30832342›Full record

ArticleInternational journal of molecular sciences2019

Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of

Charles Dahlsson Leitao, Sara S Rinne, Bogdan Mitran, Anzhelika Vorobyeva, Ken G Andersson, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Novel smallFrontiers in oncology · 2022
    Article
  7. HER3 PET Imaging:Cancers · 2021
    Article
  8. PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Pharmacokinetic Properties ofMolecules (Basel, Switzerland) · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Increase in negative charge ofScientific reports · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Charles Dahlsson LeitaoDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden. chdl@kth.se.
Sara S RinneDepartment of Medicinal Chemistry, Uppsala University, 751 23Uppsala, Sweden. sara.rinne@ilk.uu.se.
Bogdan MitranDepartment of Medicinal Chemistry, Uppsala University, 751 23Uppsala, Sweden. mitran.bogdan@ilk.uu.se.
Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85Uppsala, Sweden. anzhelika.vorobyeva@igp.uu.se.ORCID 0000-0002-4778-3909
Ken G AnderssonDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden. ken2@kth.se.
Vladimir TolmachevDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85Uppsala, Sweden. Vladimir.tolmachev@igp.uu.se.ORCID 0000-0002-6122-1734
Stefan StåhlDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden. ssta@kth.se.
John LöfblomDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden. lofblom@kth.se.ORCID 0000-0001-9423-0541
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, 751 23Uppsala, Sweden. anna.orlova@ilk.uu.se.ORCID 0000-0001-6120-2683
Uppsala University · SEKTH Royal Institute of Technology · SE

Funding

Swedish Cancer Foundation CAN2014/474, CAN 2017/425, CAN2015/350, CAN 2018/436, CAN2017/649, CAN2016/463Vetenskapsrådet 2015-02509, 2015-02353, 2012-05236VINNOVA 2016/04060
6 · The paper itself

Abstract

Affibody-based imaging of HER3 is a promising approach for patient stratification. We investigated the influence of a hydrophilic HEHEHE-tag ((HE)₃-tag) and two different gallium-68/chelator-complexes on the biodistribution of Z

Indexed as

AcetatesAnimalsCell Line, TumorChelating AgentsGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansLiverMiceMice, Inbred BALB CMice, NudePositron-Emission TomographyProtein BindingRadiopharmaceuticalsReceptor, ErbB-3Recombinant Fusion Proteins1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononaneAcetatesChelating AgentsGallium RadioisotopesHeterocyclic Compounds, 1-RingRadiopharmaceuticalsReceptor, ErbB-3Recombinant Fusion Proteinsaffibodygallium-68HER3molecular imagingNODAGANOTAPET

Identifiers

PMID30832342
PMCPMC6429182
OpenAlexW2920550720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.