ReviewNanomaterials (Basel, Switzerland)2019
Risk Analysis of Cellulose Nanomaterials by Inhalation: Current State of Science.
Review in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- NLRP3 inflammasome activation by particles and fibers: implications for human hazard assessment.Archives of toxicology · 2026Review
- Life-Cycle Risk Assessment of Second-Generation Cellulose Nanomaterials.Nanomaterials (Basel, Switzerland) · 2025Article
- Safety of Mechanically Fibrillated Cellulose Nanofibers (CNFs) by Inhalation Exposure Based on TG412.Nanomaterials (Basel, Switzerland) · 2025Article
- Article
- Structural Color from Cellulose Nanocrystals or Chitin Nanocrystals: Self-Assembly, Optics, and Applications.Chemical reviews · 2023Review
- Effects of advanced nanomaterials on the respiratory system of a murine COPD model.Toxicology reports · 2023Article
- Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers.Polymers · 2023Review
- Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure.Nanomaterials (Basel, Switzerland) · 2022Review
- Effect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils.Biomacromolecules · 2022Article
- Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils.Particle and fibre toxicology · 2022Article
- Genotoxicity assessment of cellulose nanofibrils using a standard battery ofToxicology reports · 2022Article
- Progresses in Food Packaging, Food Quality, and Safety-Controlled-Release Antioxidant and/or Antimicrobial Packaging.Molecules (Basel, Switzerland) · 2021Review
- Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats.Inhalation toxicology · 2021Article
- Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals.Chemosphere · 2020Article
- Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Review
- Nanomaterials to Enhance Food Quality, Safety, and Health Impact.Nanomaterials (Basel, Switzerland) · 2020Article
- Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine.Nanomaterials (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cellulose nanomaterials (CNs) are emerging advanced materials with many unique properties and growing commercial significance. A life-cycle risk assessment and environmental health and safety roadmap identified potential risks from inhalation of powdered CNs in the workplace as a key gap in our understanding of safety and recommended addressing this data gap to advance the safe and successful commercialization of these materials. Here, we (i) summarize the currently available published literature for its contribution to our current understanding of CN inhalation hazard and (ii) evaluate the quality of the studies for risk assessment purposes using published study evaluation tools for nanomaterials to assess the weight of evidence provided. Our analysis found that the quality of the available studies is generally inadequate for risk assessment purposes but is improving over time. There have been some advances in knowledge about the effects of short-term inhalation exposures of CN. The most recent in vivo studies suggest that short-term exposure to CNs results in transient inflammation, similarly to other poorly soluble, low toxicity dusts such as conventional cellulose, but is markedly different from fibers with known toxicity such as certain types of multiwalled carbon nanotubes or asbestos. However, several data gaps remain, and there is still a lack of understanding of the effects from long-term, low-dose exposures that represent realistic workplace conditions, essential for a quantitative assessment of potential health risk. Therefore, taking precautions when handling dry forms of CNs to avoid dust inhalation exposure is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.