Evidence map›Paper›PMID 30832289›Full record

ArticleNutrients2019

Nutrient Composition Comparison between a Modified Paleolithic Diet for Multiple Sclerosis and the Recommended Healthy U.S.-Style Eating Pattern.

Catherine A Chenard, Linda M Rubenstein, Linda G Snetselaar, Terry L Wahls

3 registry-linked trialsOpen access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04009005 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

TypeinterventionalSponsorTerry L. WahlsRan2020 to 2027Enrolled44ConditionsClinically Isolated Syndrome, Relapsing Remitting Multiple SclerosisArmsTherapeutic diet and lifestyle
NCT05007483 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Efficacy of Diet on Quality of Life in Multiple Sclerosis

TypeinterventionalSponsorTerry L. WahlsRan2022 to 2026Enrolled162ConditionsMultiple Sclerosis, Relapsing-RemittingArmsBodyBio Balance Oil, Kirunal Fish Oil, BodyBio PC, Modified Paleolithic Elimination diet, Time Restricted Olive Oil Based (TROO) Ketogenic Diet
NCT05057676 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Evaluation of an Online Course Designed to Support the Adoption of Healthier Diet and Self-Care Routines in Multiple Sclerosis Patients

TypeinterventionalSponsorTerry L. WahlsRan2021 to 2027Enrolled400ConditionsMultiple Sclerosis, Clinically Isolated Syndrome, Fibromyalgia, Post Acute Sequelae of COVID-19ArmsImmediate Autoimmune Intervention Mastery Course (AIM), Immediate Question and Answer sessions. (AIM Q and A sessions), Delayed Autoimmune Intervention Mastery Course (delayed AIM course), Delayed AIM Question and Answer sessions
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Catherine A ChenardDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. catherine-chenard@uiowa.edu.ORCID 0000-0003-3551-1516
Linda M RubensteinDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. linda-rubenstein@uiowa.edu.
Linda G SnetselaarDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. linda-snetselaar@uiowa.edu.
Terry L WahlsDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. terry-wahls@uiowa.edu.ORCID 0000-0001-6059-7994
University of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a demyelinating disease that attacks the central nervous system. Evidence-based dietary guidelines do not exist for MS; the default advice is to follow the Dietary Guidelines for Americans (DGA). A modified Paleolithic Wahls Elimination (WahlsElim) diet promoted for MS excludes grains and dairy and encourages 9+ cups fruits and vegetables (F/V) and saturated fat for cooking. This study evaluated the nutritional adequacy of seven-day menus and modeled them with varying amounts of F/V for comparison with the DGA Healthy US-Style Eating Pattern (HEP) for ages 31⁻50 years. WahlsElim menus had low added sugar and glycemic index. Nutritional adequacy of the menus and modeled versions were similar to HEP for 17 vitamins and minerals (mean adequacy ratio ≥92%). Nutrient shortfalls for the modeled diet with 60% F/V were identical to HEP for vitamin D, iron (females), magnesium (marginally males), choline and potassium; this modeled diet was also low in dietary fiber and calcium but met vitamin E requirements while HEP did not. WahlsElim-prescribed supplements corrected vitamin D and magnesium shortfalls; careful selection of foods are needed to meet requirements of other shortfall nutrients and reduce saturated fat and sodium. Doctors should monitor nutritional status, supplement doses, and possible contraindications to high vitamin K intake in individuals following the WahlsElim diet.

Indexed as

Diet, PaleolithicNutrition SurveysAdultCalcium, DietaryDietary FiberDietary SupplementsDiet, HealthyFeeding BehaviorFemaleFruitHumansMaleMiddle AgedMineralsMultiple SclerosisNutrientsCalcium, DietaryDietary FiberMineralsNutrientsVitaminsexemplary menusmultiple sclerosisnutrient densitynutritional adequacyPaleolithic dietWahls Elimination diet

Identifiers

PMID30832289
PMCPMC6470485
OpenAlexW2920656749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.