ArticleInternational journal of molecular sciences2019
Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Therapeutic Potential of Platelet-Rich Plasma in Canine Medicine.Archives of Razi Institute · 2021Pooled it
- Platelet-Rich Plasma for Bone Fracture Treatment: A Systematic Review of Current Evidence in Preclinical and Clinical Studies.Frontiers in medicine · 2021Pooled it
- Fibrin, from blood to bone: a review.Bone reports · 2026Review
- Platelet-Rich Plasma in Veterinary Orthopedic Surgery: A Systematic Review and Quality Evaluation on Liquid- and Gel-Based Therapies in Dogs.Gels (Basel, Switzerland) · 2025Review
- Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries.International journal of pharmaceutics: X · 2025Review
- Mesenchymal stromal cell isolation from pond slider (Frontiers in veterinary science · 2025Article
- Therapeutic Potential of Platelet-Rich Plasma in Fracture Healing: A Comprehensive Review.Cureus · 2024Review
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
- Incidence of Patellar Desmopathy in the Modified Maquet Technique with and without PRGF.Veterinary sciences · 2022Article
- Owner assessed outcomes following elbow arthroscopy with or without platelet rich plasma for fragmented medial coronoid process.Frontiers in veterinary science · 2022Article
- Prospects and Applications of Natural Blood-Derived Products in Regenerative Medicine.International journal of molecular sciences · 2021Review
- Platelet-Rich Plasma for the Treatment of Degenerative Lumbosacral Stenosis: A Study with Retired Working Dogs.Animals : an open access journal from MDPI · 2021Article
- Use of Autologous Leucocyte- and Platelet-Rich Plasma (L-PRP) in the Treatment of Aural Hematoma in Dogs.Veterinary sciences · 2021Article
- Does PRGF Work? A Prospective Clinical Study in Dogs with A Novel Polylactic Acid Scaffold Injected with PRGF Using the Modified Maquet Technique.Animals : an open access journal from MDPI · 2021Article
- Case Report: First Evidence of a Benign Bone Cyst in an Adult Teckel Dog Treated With Shark Teeth-Derived Bioapatites.Frontiers in veterinary science · 2021Article
- Optimization of a rapid one-step platelet-rich plasma preparation method using syringe centrifugation with and without carprofen.BMC veterinary research · 2020Article
- Platelet Function and Therapeutic Applications in Dogs: Current Status and Future Prospects.Animals : an open access journal from MDPI · 2020Review
- Application of Shark Teeth-Derived Bioapatites as a Bone Substitute in Veterinary Orthopedics. Preliminary Clinical Trial in Dogs and Cats.Frontiers in veterinary science · 2020Article
- Blood-Derived Products for Tissue Repair/Regeneration.International journal of molecular sciences · 2019Article
- In dogs does the use of bone morphogenetic proteins with internal fixation accelerates fracture healing?Veterinary evidenceReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With this objective, sixty-five dogs with radius/ulna or tibia/fibula bone fractures were randomly divided into two groups (PRGF and saline solution (SS) groups) and checked at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180. All the fractures were treated with an external skeletal fixation, and pain was controlled with Carprofen. Healing was evaluated by physical examination, limb function, radiography, and by a Likert-type owner satisfaction questionnaire. A faster fracture healing was observed in the PRGF group, with statistically significant differences with respect to the SS group. Swelling at the fracture site was significantly greater at day 14 and 28 in animals injected with PRGF, and more pain on palpation was found in the area at day 28. The injection of PRGF in acute bone fractures accelerates bone healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.