ArticleCancers2019
Pre-Operative Versus Post-Operative Radiosurgery of Brain Metastases-Volumetric and Dosimetric Impact of Treatment Sequence and Margin Concept.
Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hypofractionated stereotactic radiotherapy versus whole-brain radiotherapy following brain metastasis resection: Results of the ESTRON randomized phase 2 trial.Neuro-oncology · 2025Trial
- Trial
- Neoadjuvant stereotactic radiosurgery for brain metastases: A systematic review and meta-analysis.Neuro-oncology practice · 2026Article
- Neoadjuvant stereotactic radiosurgery for brain metastases: Current evidence and clinical perspectives.Biomolecules & biomedicine · 2025Review
- Patterns of Recurrence After Postoperative Stereotactic Radiotherapy for Brain Metastases.Cancers · 2025Article
- The existence of cranial bone flap displacement during brain radiotherapy.Technical innovations & patient support in radiation oncology · 2024Article
- Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases - Clinical outcome and prognostic factors.Clinical and translational radiation oncology · 2024Article
- Symptomatic radionecrosis after postoperative but not preoperative stereotactic radiosurgery in a single patient: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Preoperative stereotactic radiosurgery as neoadjuvant therapy for resectable brain tumors.Journal of neuro-oncology · 2023Review
- Opportunities and Alternatives of Modern Radiation Oncology and Surgery for the Management of Resectable Brain Metastases.Cancers · 2023Review
- What if: A retrospective reconstruction of resection cavity stereotactic radiosurgery to mimic neoadjuvant stereotactic radiosurgery.Frontiers in oncology · 2023Article
- Article
- Optimal timing of radiotherapy following brain metastases surgery.Neuro-oncology practice · 2022Article
- Resection cavity dynamics and optimal timing of adjuvant stereotactic radiosurgery for resected brain metastases.Journal of radiosurgery and SBRT · 2022Article
- The Impact of Postoperative Tumor Burden on Patients With Brain Metastases.Frontiers in oncology · 2022Article
- Updates on Surgical Management and Advances for Brain Tumors.Current oncology reports · 2021Review
- Review
- Article
- Stereotactic Cavity Irradiation or Whole-Brain Radiotherapy Following Brain Metastases Resection-Outcome, Prognostic Factors, and Recurrence Patterns.Frontiers in oncology · 2020Article
- Neoadjuvant Stereotactic Radiosurgery: a Further Evolution in the Management of Brain Metastases.Current oncology reports · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-operative radiosurgery (SRS) preceding the resection of brain metastases promises to circumvent limitations of post-operative cavity SRS. It minimizes uncertainties regarding delineation and safety margins and could reduce dose exposure of the healthy brain (HB).
methodsWe performed a systematic treatment plan comparison on 24 patients who received post-operative radiosurgery of the resection cavity at our institution. Comparative treatment plans were calculated for hypofractionated stereotactic radiotherapy (7 × 5 Gray (Gy)) in a hypothetical pre-operative (pre-op) and two post-operative scenarios, either with (extended field, post-op-E) or without the surgical tract (involved field, post-op-I). Detailed volumetric comparison of the resulting target volumes was performed, as well as dosimetric comparison focusing on targets and the HB.
resultsThe resection cavity was significantly smaller and different in morphology from the pre-operative lesion, yielding a low Dice Similarity Coefficient (DSC) of 53% (
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