ArticleNeuroImage2019
Anhedonia modulates the effects of positive mood induction on reward-related brain activation.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pooled it
- A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.Nature medicine · 2020Trial
- Functional connectivity during positive mood and anxiety treatment response in children.Journal of affective disorders · 2026Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.Human brain mapping · 2026Article
- The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI.Journal of affective disorders · 2024Article
- Managing Cancer and Living Meaningfully (CALM) alleviates chemotherapy related cognitive impairment (CRCI) in breast cancer survivors: A pilot study based on resting-state fMRI.Cancer medicine · 2023Article
- Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Plasticity of synapses and reward circuit function in the genesis and treatment of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- PPARα Signaling: A Candidate Target in Psychiatric Disorder Management.Biomolecules · 2022Review
- Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Kappa Opioid Receptors in the Pathology and Treatment of Major Depressive Disorder.Handbook of experimental pharmacology · 2022Review
- Neuroanatomical Correlates of Mild-to-Moderate Depression: Memory Ability Mediates the Association Between Gray Matter Volume and Antidepressant Treatment Outcome.Frontiers in neuroscience · 2022Article
- A translational perspective on the anti-anhedonic effect of ketamine and its neural underpinnings.Molecular psychiatry · 2022Review
- Effects of Appetitive and Aversive Motivational States on Wanting and Liking of Interpersonal Touch.Neuroscience · 2021Article
- A Painful Beginning: Early Life Surgery Produces Long-Term Behavioral Disruption in the Rat.Frontiers in behavioral neuroscience · 2021Article
- Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder.NeuroImage. Clinical · 2021Article
- Effects of Biological Sex and Stress Exposure on Ventromedial Prefrontal Regulation of Mood-Related Behaviors.Frontiers in behavioral neuroscience · 2021Review
- Emotional Contexts Modulate Anticipatory Late Positive Component and Reward Feedback Negativity in Adolescents With Major Depressive Disorder.Frontiers in psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Blunted activation in the reward circuitry has been associated with anhedonia, the inability to experience pleasure in previously rewarding activities. In healthy individuals, reward-related activation has been found to be modulated by acute contextual factors such as induced positive mood. Accordingly, blunted reward response in anhedonia might involve a failure to appropriately modulate reward-related activation as a function of context. To test this hypothesis, 29 participants (19 females, mean age of 24.14 ± 4.61, age range 18-34), with a wide range of anhedonic symptoms, underwent functional MRI while anticipating and receiving monetary rewards, before and after a positive mood induction. Change in neural activation from before to after mood induction was quantified, and effects of anhedonia were investigated through whole-brain, ROI, and functional connectivity analyses. Contrary to hypotheses, results indicated that during reward anticipation (but not receipt), nucleus accumbens activation decreased while its connectivity with the dorsolateral prefrontal cortex increased, following positive mood induction. Critically, anhedonia modulated both effects. The unexpected finding of decreased activation to reward cues following positive mood induction is compelling as it aligns with a prominent behavioral model of the effect of positive mood on exploration of rewarding and neutral stimuli. Furthermore, the modulation of this effect by anhedonia suggests that it may be a key process altered in anhedonia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.