Evidence map›Paper›PMID 30831269›Full record

ArticleBiochimica et biophysica acta. Gene regulatory mechanisms2019

Leukocyte integrin signaling regulates FOXP1 gene expression via FOXP1-IT1 long non-coding RNA-mediated IRAK1 pathway.

Can Shi, Jessica Miley, Alison Nottingham, Toshifumi Morooka, Domenick A Prosdocimo, Daniel I Simon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Gene regulatory mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Can ShiHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: can.shi@case.edu.
Jessica MileyHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Alison NottinghamHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Toshifumi MorookaHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Domenick A ProsdocimoHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Daniel I SimonHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
University School · USCase Western Reserve University · USUniversity Hospitals of Cleveland · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
Transdisciplinary Research on Energetics and CancerU54CA116867 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI BERGER, NATHAN A. · 2005 to 2010
$11.3M
Inflammation in Vascular Injury and RepairR37HL057506 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SIMON, DANIEL I · 2007 to 2016
$4.1M
MRP-14, CD36 and ThrombosisR01HL126645 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SIMON, DANIEL I · 2016 to 2019
$2.0M
NCI NIH HHS P30 CA043703NCI NIH HHS U54 CA116867NHLBI NIH HHS R01 HL126645NHLBI NIH HHS R37 HL057506
6 · The paper itself

Abstract

Leukocyte integrin-dependent downregulation of the transcription factor FOXP1 is required for monocyte differentiation and macrophage functions, but the precise gene regulatory mechanism is unknown. Here, we identify multi-promoter structure (P1, P2, and P3) of the human FOXP1 gene. Clustering of the β

Indexed as

Gene Expression RegulationAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell DifferentiationCell LineChromatinForkhead Transcription FactorsHistone DeacetylasesHumansInterleukin-1 Receptor-Associated KinasesMacrophage-1 AntigenMacrophagesMicePromoter Regions, GeneticRepressor ProteinsRNA, Long NoncodingCalcium-Calmodulin-Dependent Protein Kinase Type 2ChromatinForkhead Transcription FactorsFOXP1 protein, humanHistone DeacetylasesInterleukin-1 Receptor-Associated KinasesIRAK1 protein, humanMacrophage-1 AntigenRepressor ProteinsRNA, Long NoncodingFOXP1HDAC4IntegrinIRAK1lncRNAPromoter

Identifiers

PMID30831269
PMCPMC6492945
OpenAlexW2920406964

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.