Evidence map›Paper›PMID 30831189›Full record

ArticleFree radical biology & medicine2019

Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice.

Chethan Sampath, Jeremy C Sprouse, Michael L Freeman, Pandu R Gangula

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Cinnamaldehyde Protects againstInternational journal of molecular sciences · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chethan SampathDepartment of ODS & Research, School of Dentistry, Meharry Medical College, Nashville, TN, USA.
Jeremy C SprouseSchool of Graduate Studies & Research, Meharry Medical College, Nashville, TN, USA.
Michael L FreemanDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Pandu R GangulaDepartment of ODS & Research, School of Dentistry, Meharry Medical College, Nashville, TN, USA. Electronic address: pgangula@mmc.edu.
Meharry Medical College · USVanderbilt University Medical Center · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
ROLE OF NRF2 IN NITRERGIC MEDIAITED STOMACH MOTILITYSC1GM121282 · NIGMS · MEHARRY MEDICAL COLLEGE · PI GANGULA, PANDU R · 2017 to 2020
$1.4M
NIGMS NIH HHS R25 GM059994NIGMS NIH HHS SC1 GM121282NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

Diabetic gastroparesis (GP) is a clinical syndrome characterized by delayed gastric emptying (DGE). Loss of Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) led to reduced nNOSα mediated gastric motility and DGE. The molecular signaling of cinnamaldehyde (CNM) mediated Nrf2 activation and its mechanistic role on DGE were further investigated in obese/T2D female mice. Adult female homozygous Nfe2l2

Indexed as

AcroleinAnimalsAntioxidantsDiabetes ComplicationsDiabetes Mellitus, Type 2Diet, High-FatGastric EmptyingGastroparesisHumansMAP Kinase Signaling SystemMiceMuscle RelaxationNF-E2-Related Factor 2Nitric Oxide Synthase Type IObesityp38 Mitogen-Activated Protein KinasesAcroleinAntioxidantscinnamaldehydeNfe2l2 protein, mouseNF-E2-Related Factor 2Nitric Oxide Synthase Type INos1 protein, mousep38 Mitogen-Activated Protein KinasesDiabetic gastroparesisEstrogen receptorsGastric emptyingGSK-3βnNOSNrf2

Identifiers

PMID30831189
PMCPMC6738571
OpenAlexW2920219893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.