Evidence map›Paper›PMID 30831156›Full record

ArticleMolecular and biochemical parasitology2019

Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes.

Héctor Acosta, Richard Burchmore, Christina Naula, Melisa Gualdrón-López, Ender Quintero-Troconis, Ana J Cáceres, Paul A M Michels, Juan Luis Concepción, Wilfredo Quiñones

Open access · hybridAbstract read
In one paragraph

Article in Molecular and biochemical parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. ExploringAntimicrobial agents and chemotherapy · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. An Overview ofPathogens (Basel, Switzerland) · 2025
    Review
  12. Discovery of Strong 3-Nitro-2-Phenyl-International journal of molecular sciences · 2024
    Article
  13. Article
  14. Article
  15. Consumption of Galactose byPathogens (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Lipid and fatty acid metabolism in trypanosomatids.Microbial cell (Graz, Austria) · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Héctor AcostaLaboratorio de Enzimología de Parásitos, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela.
Richard BurchmoreInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Christina NaulaInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Melisa Gualdrón-LópezInstituto Salud Global, Hospital Clinic-Universitat de Barcelona, and Institute for Health Sciences Trias i Pujol, Barcelona, Spain.
Ender Quintero-TroconisLaboratorio de Enzimología de Parásitos, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela.
Ana J CáceresLaboratorio de Enzimología de Parásitos, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela.
Paul A M MichelsCentre for Immunity, Infection and Evolution and Centre for Translational and Chemical Biology, The University of Edinburgh, Edinburgh, EH9 3FL, UK.
Juan Luis ConcepciónLaboratorio de Enzimología de Parásitos, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela.
Wilfredo QuiñonesLaboratorio de Enzimología de Parásitos, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela. Electronic address: wilqui@ula.ve.
University of the Andes · VEUniversity of Glasgow · GBBarcelona Institute for Global Health · ESCentre for Immunity, Infection and Evolution · GB

Funding

Medical Research Council MR/S019650/1Wellcome TrustWellcome Trust 097821/Z/11/Z
6 · The paper itself

Abstract

In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis are compartmentalized in glycosomes, which are authentic but specialized peroxisomes. Besides glycolysis, activity of enzymes of other metabolic processes have been reported to be present in glycosomes, such as β-oxidation of fatty acids, purine salvage, pentose-phosphate pathway, gluconeogenesis and biosynthesis of ether-lipids, isoprenoids, sterols and pyrimidines. In this study, we have purified glycosomes from T. cruzi epimastigotes, collected the soluble and membrane fractions of these organelles, and separated peripheral and integral membrane proteins by Na

Indexed as

Chagas DiseaseLife Cycle StagesMicrobodiesProteomicsProtozoan ProteinsTrypanosoma cruziProtozoan ProteinsCell fractionationGlycolysisGlycosomeMass spectrometryMetabolismProteomicsTrypanosoma cruzi

Identifiers

PMID30831156
PMCPMC7082770
OpenAlexW2919801897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.