ReviewExperimental neurology2019
Sex differences in pediatric traumatic brain injury.
Review in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Pediatric traumatic brain injury elicits acute neuroinflammation and long-term changes in social, cognitive, and decision-making behaviors in male and female rats.bioRxiv : the preprint server for biology · 2026Article
- Mild pediatric traumatic brain injury has sex-specific effects on neuroimmune cells and social behavior in rats.Scientific reports · 2026Article
- A Single Concussion in Juvenile Mice Leads to Sex Specific Acute Cerebral Vascular Dysfunction and Blood-brain Border Dysfunction.Research square · 2026Article
- Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis.Journal of neuroinflammation · 2025Article
- Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals.Experimental neurology · 2025Article
- The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice.Clinical and experimental emergency medicine · 2025Article
- Alterations of Alpl and bFGF levels in peripheral tissues after mild traumatic brain injury: implications on sexual differences.Molecular biology reports · 2025Article
- Discovery of KDM5D as a novel biomarker for traumatic brain injury identified through bioinformatics analysis.Frontiers in immunology · 2025Article
- Sex Differences in Adult Incarceration After Pediatric Traumatic Brain Injury.Neurotrauma reports · 2024Article
- An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats.Journal of neuroinflammation · 2023Article
- Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data.Life (Basel, Switzerland) · 2023Review
- Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.Acta neuropathologica · 2023Article
- White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury.Metabolites · 2023Article
- A Multidimensional Approach to Assessing Factors Impacting Health-Related Quality of Life after Pediatric Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Sex-specific differences in resting-state functional brain activity in pediatric concussion.Scientific reports · 2023Article
- Fecal microbial transplantation limits neural injury severity and functional deficits in a pediatric piglet traumatic brain injury model.Frontiers in neuroscience · 2023Article
- Article
- Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock.Frontiers in medical technology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.