Evidence map›Paper›PMID 30830859›Full record

ArticleAging2019

Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging.

Maria J Knol, Alis Heshmatollah, Lotte G M Cremers, M Kamran Ikram, André G Uitterlinden, Cornelia M van Duijn, Wiro J Niessen, Meike W Vernooij, M Arfan Ikram, Hieab H H Adams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria J Knol *Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Alis Heshmatollah *Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Lotte G M Cremers *Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
M Kamran IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Wiro J NiessenDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Hieab H H AdamsDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Funding

CIHRMedical Research Council
6 · The paper itself

Abstract

Cognition in adults shows variation due to developmental and degenerative components. A recent genome-wide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to functional, clinical and neuroimaging outcomes. This study was conducted within the population-based Rotterdam Study (N=11,496, mean age 65.3±9.9 years, 58.0% female). We used lead variants for general cognitive function to construct a polygenic score (PGS), and additionally excluded developmental variants at multiple significance thresholds. A higher PGS was related to more years of education (β=0.29, p=4.3x10

Indexed as

Genetic VariationAgedBiomarkersBrainCognitionCognitive DysfunctionDementiaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNeuropsychological TestsBiomarkerscognitioncognitive reservegeneticsneuroimagingneurological disorders

Identifiers

PMID30830859
PMCPMC6428100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.