ArticleJournal of natural products2019
Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.
Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Grewiifopenes A-K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.Natural products and bioprospecting · 2024Article
- Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes.Molecules (Basel, Switzerland) · 2023Review
- Bioactive Clerodane Diterpenoids from the Leaves ofMolecules (Basel, Switzerland) · 2023Article
- Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action.Molecules (Basel, Switzerland) · 2022Review
- Characterization of Possible α-Glucosidase Inhibitors fromPlants (Basel, Switzerland) · 2022Article
- Article
- An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures.Journal of natural products · 2021Article
- Chemical Constituents from the Whole Plant of Cuscuta reflexa.Natural products and bioprospecting · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
An extract of the plant Anacolosa clarkii was obtained from the NCI Natural Products Repository, and it showed cytotoxic activity toward several types of pediatric solid tumor cell lines. Bioassay-guided fractionation led to the purification of eight new clerodane diterpenes [anacolosins A-F (1-6) and corymbulosins X and Y (7 and 8)] and two known compounds (9 and 10) that contained an isozuelanin skeleton. The structures of the new natural products were determined using 1D and 2D NMR and HRESIMS data, while the relative and absolute configurations of the compounds were assessed using a combination of
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Registered trials
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