Evidence map›Paper›PMID 30830673›Full record

ArticleCerebellum (London, England)2019

Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor.

Ruo-Yah Lai, Darya Tomishon, Karla P Figueroa, Stefan M Pulst, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulson, Vikram G Shakkottai and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Tremor in Spinocerebellar Ataxia: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Dysphagia in spinocerebellar ataxias type 1, 2, 3 and 6.Journal of the neurological sciences · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Ruo-Yah LaiDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Darya TomishonDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Susan PerlmanDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
George WilmotDepartment of Neurology, Emory University, Atlanta, GA, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Jeremy D SchmahmannDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Henry PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Vikram G ShakkottaiDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Sarah H YingDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Theresa ZesiewiczDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Khalaf BusharaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael GeschwindDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Guangbin XiaDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
S H SubramonyDepartment of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Tetsuo AshizawaHouston Methodist Research Institute, Houston, TX, USA.
Sheng-Han KuoDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. sk3295@columbia.edu.
Columbia University · USUniversity of Michigan–Ann Arbor · USUniversity of Utah · USEmory University · USHouston Methodist · USJohns Hopkins University · USMassachusetts General Hospital · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Florida · USUniversity of Minnesota · USUniversity of New Mexico · USUniversity of South Florida · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
Clinical Research Consortium for Spinocerebellar AtaxiasRC1NS068897 · NINDS · UNIVERSITY OF FLORIDA · PI ASHIZAWA, TETSUO · 2009 to 2010
$1.0M
The role of glucocerebrosidase and chaperone_mediated autophagy in Parkinsons disK08NS083738 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2013 to 2017
$940k
National Institute of Environmental Health Sciences ES009089National Institute of Neurological Disorders and Stroke (US) K08 NS083738NIEHS NIH HHS P30 ES009089NINDS NIH HHS K08 NS083738NINDS NIH HHS R01 NS104423NINDS NIH HHS RC1 NS068897Rare Disease Clinical Research Network RC1NS068897
6 · The paper itself

Abstract

Cerebellar degenerative pathology has been identified in tremor patients; however, how the degenerative pathology could contribute to tremor remains unclear. If the cerebellar degenerative pathology can directly drive tremor, one would hypothesize that tremor is likely to occur in the diseases of cerebellar ataxia and follows the disease progression in such disorders. To further test this hypothesis, we studied the occurrence of tremor in different disease stages of classical cerebellar degenerative disorders: spinocerebellar ataxias (SCAs). We further separately analyzed postural tremor and rest tremor, two forms of tremor that both involve the cerebellum. We also explored tremor in different subtypes of SCAs. We found that 18.1% of SCA patients have tremor. Interestingly, SCA patients with tremor have worse ataxia than those without tremor. When stratifying patients into mild, moderate, and severe disease stages according to the severity of ataxia, moderate and severe SCA patients more commonly have tremor than those with mild ataxia, the effect most prominently observed in postural tremor of SCA3 and SCA6 patients. Finally, tremor can independently contribute to worse functional status in SCA2 patients, even after adjusting for ataxia severity. Tremor is more likely to occur in the severe stage of cerebellar degeneration when compared to mild stages. Our results partially support the cerebellar degenerative model of tremor.

Indexed as

AdultAgedCerebellumFemaleHumansMaleMiddle AgedSpinocerebellar AtaxiasTremorCerebellumNeurodegenerationTremor

Identifiers

PMID30830673
PMCPMC6520148
OpenAlexW2918841934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.