ArticleInternational urology and nephrology2019
How to estimate renal function in patients with liver disease: choosing the most suitable equation.
Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Diagnostic value of cystatin C in acute kidney injury among patients with sepsis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Comparative Evaluation of Kidney Function Using Cystatin C and Serum Creatinine in Cirrhosis Patients: A Prospective Cross-Sectional Study.Health science reports · 2025Article
- Optimal Glomerular Filtration Rate Equations for Various Age Groups, Disease Conditions and Ethnicities in Asia: A Systematic Review.Journal of clinical medicine · 2023Review
- Effect of pegylated interferon-α2b add-on therapy on renal function in chronic hepatitis B patients: A real-world experience.Frontiers in microbiology · 2022Article
- Choosing an equation for glomerular filtration rate in decompensated cirrhosis: "Royal Free Hospital" formula is able to predict short-term mortality.International urology and nephrology · 2019Article
- Value of 2 risk prediction models in predicting the risk of atherosclerosis in patients with chronic kidney disease.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
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11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHepatitis B virus (HBV) infection is a public health challenge, especially in China. In clinical practice, HBV infection is associated with nephropathy. Impaired renal function is frequently observed in compensated Chronic Hepatitis B (CHB) and cirrhosis (LC). Thus, renal function must be monitored to avoid nephrotoxic effects before and during nucleoside analog treatment. Investigating the predictive markers of early renal dysfunction is essential. New GFR-predicting equations, based on Pcr and/or CystC, have been recently recommended in the general population, but their performance in liver disease patients has been rarely studied. In this study, we will discuss how to detect renal dysfunction in patients with HBV infection.
methodsA total of 16 LC patients and 23 CHB patients were enrolled in this study, and we collected and compared the clinical data of the two groups. The estimated glomerular filtration rates (eGFRs) were also calculated by several equations. All patients received 99mTc-DTPA dynamic radionuclide imaging examinations to obtain mGFRs as the reference standard. To evaluate the performance of any equation in the CHB and LC groups, paired t test, Pearson's correlation, Kappa analysis and Bland-Altman plots were utilized. Moreover, all 39 subjects were divided into two groups (according to GFR > 90 mL/min/1.73 m
resultsThe mGFR was 72.26 ± 20.69 mL/min/1.73 m
conclusionThe CHINAcr-cys equation may be more suitable for the estimation of GFR in Chinese patients with CHB or compensated cirrhosis. INR, creatinine, NAG, and CysC are proper biomarkers for screening renal dysfunction in Chinese patients with CHB or compensated LC.
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