Evidence map›Paper›PMID 30830647›Full record

ArticleBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy2019

Perspectives of Hospital Pharmacists Towards Biosimilar Medicines: A Survey of Polish Pharmacy Practice in General Hospitals.

Iga Pawłowska, Leszek Pawłowski, Natalia Krzyżaniak, Ivan Kocić

Open access · hybridAbstract read
In one paragraph

Article in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pharmacists' Perspectives of Biosimilars: A Systematic Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2022
    Pooled it
  3. Pooled it
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  5. Review
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  13. Clinical and Regulatory Concerns of Biosimilars: A Review of Literature.International journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Iga PawłowskaDepartment of Pharmacology, Medical University of Gdańsk, Dębowa Str. 23, 80-204, Gdańsk, Poland. iga112@gumed.edu.pl.ORCID http://orcid.org/0000-0003-1154-8824
Leszek PawłowskiDepartment of Palliative Medicine, Medical University of Gdańsk, Gdańsk, Dębinki Str. 2, 80-211, Gdańsk, Poland.ORCID http://orcid.org/0000-0003-0425-4502
Natalia KrzyżaniakDepartment of Pharmacy, Graduate School of Health, University of Technology Sydney, 638 Jones Street, Broadway, Ultimo, NSW, Australia.ORCID http://orcid.org/0000-0001-5668-7292
Ivan KocićDepartment of Pharmacology, Medical University of Gdańsk, Dębowa Str. 23, 80-204, Gdańsk, Poland.ORCID http://orcid.org/0000-0002-7363-5475
Gdańsk Medical University · PLUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere has been a significant increase in the volume of biosimilar medicines recently due to the expiries of patent protections of biologic medicines. Biosimilars are considered new medicines, and their usage in therapy is often associated with uncertainty from the perspectives of physicians, pharmacists and patients.

objectivesThe purpose of this study was to identify hospital pharmacist opinions towards these new medicines and investigate their usage in practice.

methodsA paper-based, self-administered questionnaire was distributed to Polish hospital pharmacists.

resultsBiosimilars were used in 77% of surveyed hospitals, whereas originator biologics were utilised within 90% of settings. The former medicines were found to consist of less than one-third of the entire course of biological pharmacotherapy used within Polish hospitals. A total of 88% of hospital pharmacists were concerned that the new drugs were not identical with the biologic versions, 48% with their immunogenicity and 44% with other pharmacokinetic properties. The majority of respondents (87%) stated that the most important advantage of biosimilars related to decreased costs. Furthermore, according to participants, pharmacist-led substitution is not appropriate.

conclusionDue to the numerous concerns relating to the usage of biosimilars, their introduction into patient therapy requires special attention from healthcare providers. While pharmacists involved in the distribution of biosimilars are conscious of their impact in decreasing costs of therapy, they do not feel comfortable in recommending their substitution without a physician's permission. There is a need for more precise legal regulations relating to biosimilars, improved communication between physicians and pharmacists, as well as educational initiatives to improve the safe and effective usage of biosimilars.

Indexed as

AdultAttitude of Health PersonnelBiological ProductsBiosimilar PharmaceuticalsDrug CostsDrug PrescriptionsFemaleHospitals, GeneralHumansMaleMiddle AgedPharmacistsPharmacyPolandProfessional RoleSurveys and QuestionnairesBiological ProductsBiosimilar Pharmaceuticals

Identifiers

PMID30830647
PMCPMC6439166
OpenAlexW2920607929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.