Evidence map›Paper›PMID 30830589›Full record

ArticleMolecular biology reports2019

The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data.

Yanshan Ge, Zhengxi He, Yanqi Xiang, Dawei Wang, Yuping Yang, Jian Qiu, Yanhong Zhou

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  6. The change in tumor volume after induction chemotherapy with docetaxel plus cisplatin in 259 nasopharyngeal carcinoma patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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  15. IdentifiedCancer cell international · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yanshan GeThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Zhengxi HeThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Yanqi XiangDepartment of Nursing, the Second Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China.
Dawei WangDepartment of Gastrointestinal Surgery, Tengzhou City Center People's Hospital, Zaozhuang, 277599, Shandong, China.
Yuping YangDepartment of Emergency, Tengzhou City Center People's Hospital, Zaozhuang, 277599, Shandong, China.
Jian QiuDepartment of Emergency, Tancheng City Center People's Hospital, Linyi, 276100, Shandong, China.
Yanhong ZhouThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China. zhouyanhong@csu.edu.cn.
Central South University · CNTengzhou Central People's Hospital · CNLinyi People's Hospital · CNSecond Xiangya Hospital of Central South University · CNXiangya Hospital Central South University · CN

Funding

National Natural Sciences Foundation of China 81672685, 81402270, 81272975, 81672993
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a common pattern of regional malignancy in the south of China, especially in Guangdong province. The development of computerized tomography (CT) technology and the improvement of radiotherapy scheme can improve the survival rate of NPC patients. However, the prevalence and recurrence rate of NPC are increasing every year. It is urgent for us to uncover the molecular mechanism of NPC. In this study, we used scientific information retrieval from the GEO (gene expression omnibus) database to download the GSE12452, which contained 41 samples, including 31 nasopharyngeal carcinoma samples and 10 control samples. With the help of GO (gene ontology) analysis, KEGG (kyoto encyclopedia of genes and genomes) analysis, PPI (protein-protein interaction) network model construction, and WGCNA (weighted gene co-expression network analysis), we found 6896 differentially expressed genes, which affected the biological processes included cell cycle process, DNA metabolic process, DNA repairing, immune response, cell activation, regulation of immune system process, inflammatory response. The 20 hub genes present in front of us are SYK, PIK3CG, FYN, ACACB, LRRK2, RIPK4, RAC2, PIK3CD, PTPRC, LCR, RAD51, MAD2L1, CDK1, PCNA, GMPS, CCNB1, GAPDH, CCNA2, RFC4, TOP2A. In the future, these are the areas where we need to focus on the molecular mechanism of NPC.

Indexed as

Asian PeopleBig DataCarcinoma, HepatocellularChinaComputational BiologyGene Expression ProfilingGene Expression Regulation, NeoplasticGene OntologyGene Regulatory NetworksHigh-Throughput Nucleotide SequencingHumansLiver NeoplasmsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm Recurrence, LocalProtein Interaction MapsBioinformatics analysisDifferentially expressed geneNasopharyngeal carcinoma

Identifiers

PMID30830589
OpenAlexW2920771602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.