ArticleAnnals of surgical oncology2019
Risk of Recurrence in Differentiated Thyroid Cancer: A Population-Based Comparison of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Systems.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Predicting radioiodine therapy response in advanced and recurrent thyroid cancer.Endocrine-related cancer · 2026Article
- Robust graph structure learning to improve multi-omics cancer subtype classification.BMC bioinformatics · 2026Article
- Cancer-related Fear and Worry in Patients With Low-risk Thyroid Cancer: A Longitudinal Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Molecular testing stratifies the risk of structural recurrence in high risk differentiated thyroid cancer: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Recurrent Middle Eastern Differentiated Thyroid Carcinoma Has Worse Outcomes Than Persistent Disease.Journal of clinical medicine · 2024Article
- Disparities in Thyroid Cancer Diagnosis Based on Residence and Distance From Medical Facility.Journal of the Endocrine Society · 2024Article
- Thyroidkeeper: a healthcare management system for patients with thyroid diseases.Health information science and systems · 2023Article
- Prognostic Utility of Tumor Stage versus American Thyroid Association Risk Class in Thyroid Cancer.The Laryngoscope · 2023Article
- Clinical outcomes of multifocal papillary thyroid cancer: A systematic review and meta-analysis.Laryngoscope investigative otolaryngology · 2022Review
- Extrathyroidal extension and cervical node infiltration are associated with recurrences and shorter recurrence-free survival in differentiated thyroid cancer: a cohort study.Thyroid research · 2022Article
- Concepts of Pathological Staging and Prognosis in Papillary Thyroid Carcinoma.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Ultrasound images-based deep learning radiomics nomogram for preoperative prediction ofFrontiers in endocrinology · 2022Article
- The Role of Node Dissection for Thyroid Cancer.Advances in surgery · 2021Review
- Prognostic evaluation model for papillary thyroid cancer: a retrospective study of 660 cases.Gland surgery · 2021Article
- A new proposed tumor-node-metastasis-age staging system for stage IV medullary thyroid carcinoma based on the SEER database.American journal of translational research · 2021Article
- The Prognostic Value of MicroRNAs in Thyroid Cancers-A Systematic Review and Meta-Analysis.Cancers · 2020Article
- Primary Care Provider Involvement in Thyroid Cancer Survivorship Care.The Journal of clinical endocrinology and metabolism · 2020Article
- Is a simplified TNM staging system more clinically relevant than the American Joint Committee on Cancer system for the follicular variant of papillary thyroid cancer?Annals of translational medicine · 2020Article
- Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar.International journal of surgery case reports · 2020Article
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7 authors.
Funding
Abstract
backgroundDifferentiated thyroid cancer (DTC) survival is excellent, making recurrence a more clinically relevant prognosticator. We hypothesized that the new American Joint Committee on Cancer (AJCC) 8th edition improves on the utility of the 7th edition in predicting the risk of recurrence in DTC.
methodsA population-based retrospective review compared the risk of recurrence in patients with DTC according to the AJCC 7th and 8th editions using the Surveillance, Epidemiology, and End Results-based Kentucky Cancer Registry from 2004 to 2012.
resultsA total of 3248 patients with DTC were considered disease-free after treatment. Twenty percent of patients were downstaged from the 7th edition to the 8th edition. Most patients had stage I disease (80% in the 7th edition and 94% in the 8th edition). A total of 110 (3%) patients recurred after a median of 27 months. The risk of recurrence was significantly associated with stage for both editions (p < 0.001). In the 7th edition, there was poor differentiation between lower stages and better differentiation between higher stages (stage II hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.39-2.11; stage III HR 3.72, 95% CI 2.29-6.07; stage IV HR 11.66, 95% CI 7.10-19.15; all compared with stage I). The 8th edition better differentiated lower stages (stage II HR 4.06, 95% CI 2.38-6.93; stage III HR 13.07, 95% CI 5.30-32.22; stage IV 11.88, 95% CI 3.76-37.59; all compared with stage I).
conclusionsThe AJCC 8th edition better differentiates the risk of DTC recurrence for early stages of disease compared with the 7th edition. However, limitations remain, emphasizing the importance of adjunctive strategies to estimate the risk of recurrence.
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