Evidence map›Paper›PMID 30830535›Full record

Trial reportAnnals of surgical oncology2019

Elective Paratracheal Lymph Node Dissection in Salvage Laryngectomy.

Janice L Farlow, Andrew C Birkeland, Andrew J Rosko, Kyle VanKoevering, Catherine T Haring, Joshua D Smith, J Chad Brenner, Andrew G Shuman, Steven B Chinn, Chaz L Stucken and 9 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. The role of central neck dissection and adjuvant treatment in pT4aN0 laryngeal carcinoma treated with open partial horizontal laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Janice L FarlowDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Andrew C BirkelandDepartment of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA, USA.
Andrew J RoskoDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Kyle VanKoeveringDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Catherine T HaringDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Joshua D SmithDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
J Chad BrennerDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Andrew G ShumanDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Steven B ChinnDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Chaz L StuckenDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Kelly M MalloyDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Jeffrey S MoyerDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Keith A CasperDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Scott A McLeanDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Mark E P PrinceDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Carol R BradfordDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Douglas B ChepehaDepartment of Otolaryngology, University of Toronto, Toronto, ON, Canada.
Matthew E SpectorDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA. mspector@med.umich.edu.
University of Michigan–Ann Arbor · USStanford University · USUniversity of Toronto · CA

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Dissecting Co-Dependent Pathways in Oral CancersU01DE025184 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, JOHN CHADWICK, CAREY, THOMAS E. · 2015 to 2018
$3.7M
Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8M
National Institutes of Health P30-CA046592National Institutes of Health R01-CA194536National Institutes of Health U01-DE025184NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA194536NIDCR NIH HHS U01 DE025184
6 · The paper itself

Abstract

backgroundIndications for and efficacy of paratracheal nodal dissection (PTND) in patients undergoing laryngectomy (salvage) for persistent or recurrent laryngeal squamous cell carcinoma are not well-defined.

methodsA retrospective cohort study was performed for patients undergoing salvage laryngectomy with clinically and radiographically negative neck disease between 1998 and 2015 (n = 210). Univariate and multivariate Cox regression analyses were performed.

resultsPTND was performed on 77/210 patients (36%). The PTND cohort had a greater proportion of advanced T classification (rT3/rT4) tumors (78%) than subjects without PTND (55%; p = 0.001). There was a 14% rate of occult nodal metastases in the paratracheal basin; of these, 55% did not have pathologic lateral neck disease. Multivariate analysis controlling for tumor site, tumor stage, and pathologic lateral neck disease demonstrated that PTND was associated with improved overall survival [OS] (p = 0.03; hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.38-0.96), disease-free survival [DFS] (p = 0.03; HR 0.55, 95% CI 0.31-0.96), and distant DFS survival (p = 0.01; HR 0.29, 95% CI 0.11-0.77). The rate of hypocalcemia did not differ between subjects who underwent bilateral PTND, unilateral PTND, or no PTND (p = 0.19 at discharge, p = 0.17 at last follow-up).

conclusionsPTND at the time of salvage laryngectomy was more common in patients with rT3/rT4 tumors and was associated with improved OS and DFS, with no effect on hypocalcemia. In patients undergoing PTND, the finding of occult paratracheal metastases was often independent of lateral neck metastases.

Indexed as

Salvage TherapyCarcinoma, Squamous CellElective Surgical ProceduresFemaleFollow-Up StudiesHumansLaryngeal NeoplasmsLaryngectomyLymph Node ExcisionLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesSurvival Rate

Identifiers

PMID30830535
PMCPMC6612310
OpenAlexW2919544782

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.