ArticleEJNMMI physics2019
Quantitative SPECT: the time is now.
Article in EJNMMI physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Development of [111In]In-CHX-A″-DTPA-αCD68 for ImmunoSPECT to Image Murine Macrophages.Molecular pharmaceutics · 2026Article
- Estimation of effective half-life and lesion-specific kinetics in I-131 therapy for differentiated thyroid cancer using dual-timepoint imaging.EJNMMI physics · 2026Article
- Current Position of Nuclear Medicine Imaging in Primary Bone Tumors.Diagnostics (Basel, Switzerland) · 2025Review
- Long Axial Field-of-view PET: A New Era of Quantitative PET Imaging for Theranostic Applications in Clinic.PET clinics · 2025Review
- Predictive Value ofDiagnostics (Basel, Switzerland) · 2025Article
- Pulmonary uptake value (PUV): a new quantification method for lung PET/CT imaging.EJNMMI research · 2025Article
- Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025Review
- Robustness of textural analysis features in quantitativeEJNMMI physics · 2025Article
- Whole-Body SPECT/CT: Protocol Variation and Technical Consideration-A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Technological Advances in SPECT and SPECT/CT Imaging.Diagnostics (Basel, Switzerland) · 2024Review
- Feasibility study of radioactivity estimation ofRadiological physics and technology · 2024Article
- Deep transformer-based personalized dosimetry from SPECT/CT images: a hybrid approach for [European journal of nuclear medicine and molecular imaging · 2024Article
- A look at radiation detectors and their applications in medical imaging.Japanese journal of radiology · 2024Review
- A Review on the Use of Imaging Biomarkers in Oncology Clinical Trials: Quality Assurance Strategies for Technical Validation.Tomography (Ann Arbor, Mich.) · 2023Review
- Quantitative vs. Qualitative SPECT-CT Diagnostic Accuracy in Bone Lesion Evaluation-A Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
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- Editorial: New trends in single photon emission computed tomography (SPECT).Frontiers in medicine · 2023Article
- Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates.Frontiers in nuclear medicine · 2023Article
- Quantification and dosimetry of small volumes including associated uncertainty estimation.EJNMMI physics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative measures to absolute quantification in terms of activity concentration, and yet further to normalised uptake using the standard uptake value (SUV). This expansion of quantitative SPECT has the potential to be a useful tool in the nuclear medicine armoury, but key factors must be addressed before it can meet its full potential. DISCUSSION: Quantitative SPECT should address an unmet clinical need and give metrics that are clinically meaningful. Using the technique in a similar manner to PET with longitudinal assessments of disease in terms of SUV is one example that meets these criteria. Having metrics that are evaluated to ensure that they are correct, that are optimised to maximise their sensitivity, and that are transferrable to allow multi-centre learning and applicability to all users of the technology are other areas of quantitative SPECT that need to be addressed and that have specific challenges associated with them. Finally, ensuring quantitative SPECT is cost-effective in times when healthcare budgets are being squeezed is also very important.
conclusionQuantitative SPECT offers the possibility to continue and expand the potential of quantitative nuclear medicine applications. The time is now to ensure that our community works together to make this potential a reality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.