ArticleMetabolomics : Official journal of the Metabolomic Society2019
Increased urea availability promotes adjustments in C/N metabolism and lipid content without impacting growth in Chlamydomonas reinhardtii.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Metabolic Profile ofPlants (Basel, Switzerland) · 2026Article
- DUR3 as a Molecular Lever for Coordinated Nitrogen and Phosphorus Uptake in Microalgae.Biology · 2026Article
- Microbial conversion of biodiesel waste for carotenoid production.Frontiers in bioengineering and biotechnology · 2026Article
- Development and reutilisation of a fertiliser-based culture medium for the commercial production of Chlorella sorokiniana.Scientific reports · 2025Article
- High-density heterotrophic cultivation of a cell-wall-deficient Chlamydomonas reinhardtii strain by fed-batch strategy.Biotechnology letters · 2025Article
- OptimizingFoods (Basel, Switzerland) · 2024Article
- Review
- Microalgae as Contributors to Produce Biopolymers.Marine drugs · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe use of urea as a nitrogen (N) source by Chlorophytes usually enhances biomass and lipid production when compared to ammonium (NH
objectivesThis study aimed: (i) to characterize the metabolism of C. reinhardtii cultivated in media containing only urea as N source as well as combined with different NH
methodsSpecific quantification of metabolites using 96-well microplates, and high-performance liquid chromatography combined with non-targeted metabolite profiling by gas chromatography (GC)-time-of-flight (TOF)-mass spectrometry (MS) were used in this study. In addition, GC analysis was used to determine fatty acid profiling.
resultsThe use of urea did not alter the growth rate in comparison with NH
conclusionsThese results indicate that urea promotes remarkable adjustments in metabolism, without drastic changes in biomass, promoting changes in carbohydrate and amino acid metabolism, as well as in lipids production and fatty acid profile.
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Registered trials
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