ArticleMetabolomics : Official journal of the Metabolomic Society2018
Metabolite variation in the lettuce gene pool: towards healthier crop varieties and food.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Trial
- Integrated Metabolomics and Selection Signal Analysis Provide Insights Into the Selection for Flavonol Biosynthesis Associated With Lettuce Quality Improvement.Plant biotechnology journal · 2026Article
- Spinach (Foods (Basel, Switzerland) · 2025Article
- Unraveling the variation, phylogeny, and taxonomy of Lactuca spp. for germplasm management and breeding.Planta · 2025Review
- Integration of crop modeling and sensing into molecular breeding for nutritional quality and stress tolerance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Classification of Packaged Vegetable Soybeans Based on Freshness by Metabolomics Combined with Convolutional Neural Networks.Metabolites · 2025Article
- Studies of genetic diversity and genome-wide association for vitamin C content in lettuce (Lactuca sativa L.) using high-throughput SNP arrays.The plant genome · 2024Article
- Spatio-Temporal Dynamics of Lettuce Metabolome: A Framework for Targeted Nutritional Quality Improvement.Plants (Basel, Switzerland) · 2024Article
- Impact of drought stress on vitamin C and anthocyanin content in cultivated lettuces (Frontiers in plant science · 2024Article
- Unravelling the seasonal dynamics of the metabolome of white asparagus spears using untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Lettuce Production in Intelligent Greenhouses-3D Imaging and Computer Vision for Plant Spacing Decisions.Sensors (Basel, Switzerland) · 2023Article
- LettuceGDB: The community database for lettuce genetics and omics.Plant communications · 2023Article
- Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species.NPJ science of food · 2022Article
- NMR Metabolomics and Chemometrics of Lettuce,Plants (Basel, Switzerland) · 2022Article
- Plant Response to Mechanically-Induced Stress: A Case Study on Specialized Metabolites of Leafy Vegetables.Plants (Basel, Switzerland) · 2021Article
- Plant-Growth-Promoting Rhizobacteria Emerging as an Effective Bioinoculant to Improve the Growth, Production, and Stress Tolerance of Vegetable Crops.International journal of molecular sciences · 2021Review
- Metabolomics Reveals Heterogeneity in the Chemical Composition of Green and White Spears of Asparagus (Metabolites · 2021Article
- Isolating an active and inactive CACTA transposon from lettuce color mutants and characterizing their family.Plant physiology · 2021Article
- Sequential Changes in Antioxidant Potential of Oakleaf Lettuce Seedlings Caused by Nano-TiONanomaterials (Basel, Switzerland) · 2021Article
- Stem Lettuce and Its Metabolites: Does the Variety Make Any Difference?Foods (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionLettuce (Lactuca sativa L.) is generally not specifically acknowledged for its taste and nutritional value, while its cultivation suffers from limited resistance against several pests and diseases. Such key traits are known to be largely dependent on the ability of varieties to produce specific phytochemicals.
objectivesWe aimed to identify promising genetic resources for the improvement of phytochemical composition of lettuce varieties.
methodsPhytochemical variation was investigated using 150 Lactuca genebank accessions, comprising a core set of the lettuce gene pool, and resulting data were related to available phenotypic information.
resultsA hierarchical cluster analysis of the variation in relative abundance of 2026 phytochemicals, revealed by untargeted metabolic profiling, strongly resembled the known lettuce gene pool structure, indicating that the observed variation was to a large extent genetically determined. Many phytochemicals appeared species-specific, of which several are generally related to traits that are associated with plant health or nutritional value. For a large number of phytochemicals the relative abundance was either positively or negatively correlated with available phenotypic data on resistances against pests and diseases, indicating their potential role in plant resistance. Particularly the more primitive lettuces and the closely related wild relatives showed high levels of (poly)phenols and vitamin C, thus representing potential genetic resources for improving nutritional traits in modern crop types.
conclusionOur large-scale analysis of phytochemical variation is unprecedented in lettuce and demonstrated the ample availability of suitable genetic resources for the development of improved lettuce varieties with higher nutritional quality and more sustainable production.
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