ArticleMetabolomics : Official journal of the Metabolomic Society2018
Metabolite and gene expression profiles suggest a putative mechanism through which high dietary carbohydrates reduce the content of hepatic betaine in Megalobrama amblycephala.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Glycogenic hepatopathy in a primitive teleost fish model: the inductive effect of high carbohydrate diet and the alleviating role of betaine.Marine life science & technology · 2026Article
- Betaine Alleviated the Ammonia-Induced Apoptosis and Inflammation in the Skin of Largemouth Bass Fed With High-Carbohydrate Diet via Inhibiting MAPK/NFκB-Myd88 Pathway.Aquaculture nutrition · 2025Article
- Betaine Supplementation Into High-Carbohydrate Diets Improves Feed Efficiency and Liver Health ofAquaculture nutrition · 2024Article
- Metabolites, gene expression, and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g-ABA contents in Megalobrama amblycephala.Fish physiology and biochemistry · 2023Article
- Metabolic responses of Chinese perch (Siniperca chuatsi) to different levels of dietary carbohydrate.Fish physiology and biochemistry · 2021Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHigh-carbohydrate diets (HCD) are favoured by the aquaculture industry for economic reasons, but they can produce negative impacts on growth and induce hepatic steatosis. We hypothesised that the mechanism behind this is the reduction of hepatic betaine content.
objectiveWe further explored this mechanism by supplementing betaine (1%) to the diet of a farmed fish Megalobrama amblycephala.
methodsFour diet groups were designed: control (CD, 27.11% carbohydrates), high-carbohydrate (HCD, 36.75% carbohydrates), long-term betaine (LBD, 35.64% carbohydrates) and short-term betaine diet (SBD; 12 weeks HCD + 4 weeks LBD). We analysed growth performance, body composition, liver condition, and expression of genes and profiles of metabolites associated with betaine metabolism.
resultsHCD resulted in poorer growth and liver health (compared to CD), whereas LBD improved these parameters (compared to HCD). HCD induced the expression of genes associated with glucose, serine and cystathionine metabolisms, and (non-significantly, p = .20) a betaine-catabolizing enzyme betaine-homocysteine-methyltransferase; and decreased the content of betaine, methionine, S-adenosylhomocysteine and carnitine. Betaine supplementation (LBD) reversed these patterns, and elevated betaine-homocysteine-methyltransferase, S-adenosylmethionine and S-adenosylhomocysteine (all p ≤ .05).
conclusionWe hypothesise that HCD reduced the content of hepatic betaine by enhancing the activity of metabolic pathways from glucose to homocysteine, reflected in increased glycolysis, serine metabolism, cystathionine metabolism and homocysteine remethylation. Long-term dietary betaine supplementation improved the negative impacts of HCD, inculding growth parameters, body composition, liver condition, and betaine metabolism. However, betaine supplementation may have caused a temporary disruption in the metabolic homeostasis.
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