Evidence map›Paper›PMID 30830416›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2019

Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.

A L O'Kell, T J Garrett, C Wasserfall, M A Atkinson

Open access · greenAbstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Metabolomics in the study of spontaneous animal diseases.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020
    Review
  12. Canine metabolomics advances.Metabolomics : Official journal of the Metabolomic Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A L O'KellDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Florida, Box 100116, 2015 SW 16th Avenue, Gainesville, FL, 32608, USA. aokell@ufl.edu.ORCID 0000-0002-3412-0575
T J GarrettDepartment of Pathology, Immunology, and Laboratory Medicine, The University of Florida, 1395 Center Drive, Gainesville, FL, 32610, USA.
C WasserfallDepartment of Pathology, Immunology, and Laboratory Medicine, The University of Florida Diabetes Institute, 1275 Center Drive, Gainesville, FL, 32610, USA.
M A AtkinsonDepartments of Pathology, Immunology and Laboratory Medicine, and Pediatrics, The University of Florida Diabetes Institute, 1275 Center Drive, Gainesville, FL, 32610, USA.
University of Florida · US

Funding

Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9M
Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Evaluating canine diabetes as a novel means to understand the human diseaseK08DK116735 · NIDDK · UNIVERSITY OF FLORIDA · PI O'KELL, ALLISON L · 2018 to 2021
$598k
NCATS NIH HHS KL2 TR001429NIAID NIH HHS P01 AI042288NIDDK NIH HHS K08 DK116735NIDDK NIH HHS U24 DK097209
6 · The paper itself

Abstract

introductionWe recently identified variances in serum metabolomic profiles between fasted diabetic and healthy dogs, some having similarities to those identified in human type 1 diabetes.

objectivesCompare untargeted metabolomic profiles in the non-fasted state.

methodsSerum from non-fasted diabetic (n = 6) and healthy control (n = 6) dogs were analyzed by liquid chromatography-high resolution mass spectrometry.

resultsClear clustering of metabolites between groups were observed, with multiple perturbations identified that were similar to those previously observed in fasted diabetic dogs.

conclusionThese findings further support the development of targeted assays capable of detecting metabolites that may be useful as biomarkers of canine diabetes.

Indexed as

AnimalsBiomarkersChromatography, High Pressure LiquidChromatography, LiquidCluster AnalysisDiabetes MellitusDogsMetabolomeMetabolomicsTandem Mass SpectrometryBiomarkersBiomarkersCanine diabetes mellitusHigh resolution mass spectrometryMetabolitesType 1 diabetesUltra high performance liquid chromatographyUntargeted metabolomics

Identifiers

PMID30830416
PMCPMC6461041
OpenAlexW2911349210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.