ArticleMetabolomics : Official journal of the Metabolomic Society2018
A multidimensional
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multi-Solvent Suppression Ultrafast 2D COSY for High-Throughput Wine Screening.Magnetic resonance in chemistry : MRC · 2026Article
- Nonliving respiration: Another breath in the soil?Science advances · 2025Article
- NMR methods for the analysis of mixtures.Chemical communications (Cambridge, England) · 2022Review
- Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.Frontiers in endocrinology · 2022Review
- Metabolomics in Retinal Diseases: An Update.Biology · 2021Review
- Extending the Lipidome Coverage by Combining Different Mass Spectrometric Platforms: An Innovative Strategy to Answer Chemical Food Safety Issues.Foods (Basel, Switzerland) · 2021Article
- Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives.Frontiers in molecular biosciences · 2021Review
- Combining rapid 2D NMR experiments with novel pre-processing workflows and MIC quality measures for metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Two data pre-processing workflows to facilitate the discovery of biomarkers by 2D NMR metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Quantification of Lipids: Model, Reality, and Compromise.Biomolecules · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough it is still at a very early stage compared to its mass spectrometry (MS) counterpart, proton nuclear magnetic resonance (NMR) lipidomics is worth being investigated as an original and complementary solution for lipidomics. Dedicated sample preparation protocols and adapted data acquisition methods have to be developed to set up an NMR lipidomics workflow; in particular, the considerable overlap observed for lipid signals on 1D spectra may hamper its applicability.
objectivesThe study describes the development of a complete proton NMR lipidomics workflow for application to serum fingerprinting. It includes the assessment of fast 2D NMR strategies, which, besides reducing signal overlap by spreading the signals along a second dimension, offer compatibility with the high-throughput requirements of food quality characterization.
methodThe robustness of the developed sample preparation protocol is assessed in terms of repeatability and ability to provide informative fingerprints; further, different NMR acquisition schemes-including classical 1D, fast 2D based on non-uniform sampling or ultrafast schemes-are evaluated and compared. Finally, as a proof of concept, the developed workflow is applied to characterize lipid profiles disruption in serum from β-agonists diet fed pigs.
resultsOur results show the ability of the workflow to discriminate efficiently sample groups based on their lipidic profile, while using fast 2D NMR methods in an automated acquisition framework.
conclusionThis work demonstrates the potential of fast multidimensional
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