ArticleMetabolomics : Official journal of the Metabolomic Society2018
Serum metabolomic profiles associated with postmenopausal hormone use.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of hormone therapy on tryptophan metabolism and atherosclerosis among postmenopausal women.Climacteric : the journal of the International Menopause Society · 2025Trial
- Network propagation in bipartite metabolite-reaction graphs for metabolomic data exploration.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- A Comparative Study of Network-Based Machine Learning Approaches for Binary Classification in Metabolomics.Metabolites · 2025Article
- MetaboLights: open data repository for metabolomics.Nucleic acids research · 2024Article
- Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study.Frontiers in oncology · 2023Article
- IDSL.IPA Characterizes the Organic Chemical Space in Untargeted LC/HRMS Data Sets.Journal of proteome research · 2022Article
- CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets.Environment international · 2022Article
- Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study.The European respiratory journal · 2022Article
- Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer.Oncogene · 2022Article
- Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis.PLoS computational biology · 2021Article
- Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine.Journal of proteome research · 2021Article
- Metabolomic Effects of Hormone Therapy and Associations With Coronary Heart Disease Among Postmenopausal Women.Circulation. Genomic and precision medicine · 2020Observational
- Validation of plasma metabolites associated with breast cancer risk among Mexican Americans.Cancer epidemiology · 2020Article
- On the Use of Correlation and MI as a Measure of Metabolite-Metabolite Association for Network Differential Connectivity Analysis.Metabolites · 2020Article
- Metabolic Fingerprint of Turner Syndrome.Journal of clinical medicine · 2020Article
- A comparative evaluation of the generalised predictive ability of eight machine learning algorithms across ten clinical metabolomics data sets for binary classification.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Prospective analysis of circulating metabolites and breast cancer in EPIC.BMC medicine · 2019Article
- Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria.Frontiers in neuroendocrinology · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostmenopausal hormone use is linked to several health outcomes and the risk associated with some may differ depending on whether estrogen is used alone or in combination with progestin.
objectiveMetabolomic analyses of postmenopausal hormone use and differences between hormone regimes was done to identify metabolites associated with each type of hormone treatment.
methodsUntargeted metabolomics analysis was done on serum from 1336 women enrolled in the Cancer Prevention II Nutrition Cohort. Levels of 781 named metabolites were compared between 667 nonusers with 332 estrogen-only and with 337 estrogen plus progestin users using linear regression. Metabolite levels were also compared between estrogen-only and estrogen plus progestin users.
resultsCompared to nonusers, 276 metabolites were statistically significantly (P < 6.40 × 10
conclusionsThese findings suggest that postmenopausal hormone use influences metabolic pathways linked to a variety of cellular processes, including the regulation of metabolism and stress responses, energy production, and inflammation. The differential association of numerous lipids which influence cellular signaling suggests that differences in signal transduction may contribute to the disparate risks for some diseases between estrogen-only and estrogen plus progestin users.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.