ArticleMetabolomics : Official journal of the Metabolomic Society2018
Comparative analysis of creatinine and osmolality as urine normalization strategies in targeted metabolomics for the differential diagnosis of asthma and COPD.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD.Journal of translational medicine · 2024Article
- Ameliorative effect ofSaudi journal of biological sciences · 2023Article
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- Metabolite quantification: A fluorescence-based method for urine sample normalization prior toMetabolomics : Official journal of the Metabolomic Society · 2022Article
- Prostanoid Metabolites as Biomarkers in Human Disease.Metabolites · 2022Review
- Metabolomics study of blood pressure salt-sensitivity and hypertension.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
- Comprehensive Targeted Metabolomic Study in the Lung, Plasma, and Urine of PPE/LPS-Induced COPD Mice Model.International journal of molecular sciences · 2022Article
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- Immune cell profiles of patients with interstitial cystitis/bladder pain syndrome.Journal of translational medicine · 2022Article
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- Research Progress of Metabolomics in Asthma.Metabolites · 2021Review
- Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.Environment international · 2021Article
- One mutation, three phenotypes: novel metabolic insights on MELAS, MIDD and myopathy caused by the m.3243A > G mutation.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- A review of strategies for untargeted urinary metabolomic analysis using gas chromatography-mass spectrometry.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Evaluation of statistical techniques to normalize mass spectrometry-based urinary metabolomics data.Journal of pharmaceutical and biomedical analysis · 2020Article
- Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches.Metabolites · 2019Article
- Article
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5 authors.
Funding
Abstract
introductionUrine is an ideal matrix for metabolomics investigation due to its non-invasive nature of collection and its rich metabolite content. Despite the advancements in mass spectrometry and
objectiveTo assess whether the statistical model of separation of diseases using targeted metabolomic data would be improved by normalization to osmolality instead of creatinine.
methodsThe concentration of 32 metabolites was previously measured by two liquid chromatography-tandem mass spectrometry methods in 51 human urine samples with either asthma (n = 25) or COPD (n = 26). The data was normalized to creatinine or osmolality. Statistical analysis of the normalized values in each disease was performed using partial least square discriminant analysis (PLS-DA). Models of separation of diseases were compared.
resultsWe found that normalization to creatinine or osmolality did not significantly change the PLS-DA models of separation (R
conclusionOur findings suggest that targeted urine metabolomic data can be normalized for hydration using creatinine or osmolality with no significant impact on the diagnostic accuracy of the model.
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