ArticleMetabolomics : Official journal of the Metabolomic Society2018
The altered human serum metabolome induced by a marathon.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans.Journal of translational medicine · 2026Trial
- Review
- Dried blood spots capture a wide range of metabolic pathways and biological changes associated with exercise.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Acute metabolite responses to swimming exercise of different intensities in highly trained male and female swimmers.Physiological reports · 2025Article
- Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.Physiological reports · 2025Article
- Sample Preparation for Metabolomic Analysis in Exercise Physiology.Biomolecules · 2024Review
- The metabolic consequences of HIV/TB co-infection.BMC infectious diseases · 2023Article
- The metabolic recovery of marathon runners: an untargetedFrontiers in physiology · 2023Article
- Research on sweat metabolomics of athlete's fatigue induced by high intensity interval training.Frontiers in physiology · 2023Article
- Comparison of the effects of pea protein and whey protein on the metabolic profile of soccer athletes: a randomized, double-blind, crossover trial.Frontiers in nutrition · 2023Article
- Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men-A multi-platform metabolomics approach.Frontiers in physiology · 2023Article
- Initial military training modulates serum fatty acid and amino acid metabolites.Physiological reports · 2022Article
- The rating of perceived exertion is able to differentiate the post-matches metabolomic profile of elite U-20 soccer players.European journal of applied physiology · 2022Article
- Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions.Frontiers in molecular biosciences · 2022Article
- Beetroot juice - a suitable post-marathon metabolic recovery supplement?Journal of the International Society of Sports Nutrition · 2021Review
- Serum Branched-Chain Amino Acid Metabolites Increase in Males When Aerobic Exercise Is Initiated with Low Muscle Glycogen.Metabolites · 2021Article
- Characterizing Marathon-Induced Metabolic Changes UsingMetabolites · 2021Article
- "Fuel for the Damage Induced": Untargeted Metabolomics in Elite Rugby Union Match Play.Metabolites · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEndurance races have been associated with a substantial amount of adverse effects which could lead to chronic disease and long-term performance impairment. However, little is known about the holistic metabolic changes occurring within the serum metabolome of athletes after the completion of a marathon.
objectivesConsidering this, the aim of this study was to better characterize the acute metabolic changes induced by a marathon.
methodsUsing an untargeted two dimensional gas chromatography time-of-flight mass spectrometry metabolomics approach, pre- and post-marathon serum samples of 31 athletes were analyzed and compared to identify those metabolites varying the most after the marathon perturbation.
resultsPrinciple component analysis of the comparative groups indicated natural differentiation due to variation in the total metabolite profiles. Elevated concentrations of carbohydrates, fatty acids, tricarboxylic acid cycle intermediates, ketones and reduced concentrations of amino acids indicated a metabolic shift between various fuel substrate systems. Additionally, elevated odd-chain fatty acids and α-hydroxy acids indicated the utilization of α-oxidation and autophagy as alternative energy-producing mechanisms. Adaptations in gut microbe-associated markers were also observed and correlated with the metabolic flexibility of the athlete.
conclusionFrom these results it is evident that a marathon places immense strain on the energy-producing pathways of the athlete, leading to extensive protein degradation, oxidative stress, mammalian target of rapamycin complex 1 inhibition and autophagy. A better understanding of this metabolic shift could provide new insights for optimizing athletic performance, developing more efficient nutrition regimens and identify strategies to improve recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.