ArticleMetabolomics : Official journal of the Metabolomic Society2018
Diagnosis of Clostridium difficile infection using an UPLC-MS based metabolomics method.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- High-resolution metabolomic analysis of stool reveals expanded biomarkers ofMicrobiology spectrum · 2026Article
- Fecal Metabolomics for the Diagnosis ofDiagnostics (Basel, Switzerland) · 2025Article
- Dual-functionality of Nocardiopsis alba B57 in biocontrol and plant growth: a metabolomic approach to agricultural sustainability.NPJ biofilms and microbiomes · 2025Article
- Metabonomic analysis to identify exometabolome changes underlying antifungal and growth promotion mechanisms of endophytic ActinobacteriumFrontiers in microbiology · 2024Article
- Investigating gut microbiota-blood and urine metabolite correlations in early sepsis-induced acute kidney injury: insights from targeted KEGG analyses.Frontiers in cellular and infection microbiology · 2024Observational
- Advances in diagnostic assays forFrontiers in cellular and infection microbiology · 2024Review
- Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy.Pediatrics · 2023Review
- Article
- Metabolomics in hepatocellular carcinoma: From biomarker discovery to precision medicine.Frontiers in medical technology · 2022Review
- Synergistic effect of co-culture rhizosphereFrontiers in microbiology · 2022Article
- Metabolomics in infectious diseases and drug discovery.Molecular omics · 2021Review
- The related mechanism of complete Freund's adjuvant-induced chronic inflammation pain based on metabolomics analysis.Biomedical chromatography : BMC · 2021Article
- Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.Metabolites · 2020Review
- Establishment of a pattern recognition metabolomics model for the diagnosis of hepatocellular carcinoma.World journal of gastroenterology · 2020Article
- Metabolomics biotechnology, applications, and future trends: a systematic review.RSC advances · 2019Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
introductionThe fecal metabolome of Clostridium difficile (CD) infection is far from being understood, particularly its non-volatile organic compounds. The drawbacks of current tests used to diagnose CD infection hinder their application.
objectiveThe aims of this study were to find new characteristic fecal metabolites of CD infection and develop a metabolomics model for the diagnosis of CD infection.
methodsUltra-performance liquid chromatography-mass spectrometry (UPLC-MS) was used to characterize the fecal metabolome of CD positive and negative diarrhea and healthy control stool samples.
resultsDiarrhea and healthy control samples showed distinct clusters in the principal components analysis score plot, and CD positive group and CD negative group demonstrated clearer separation in a partial least squares discriminate analysis model. The relative abundance of sphingosine, chenodeoxycholic acid, phenylalanine, lysophosphatidylcholine (C16:0), and propylene glycol stearate was higher, and the relative abundance of fatty amide, glycochenodeoxycholic acid, tyrosine, linoleyl carnitine, and sphingomyelin was lower in CD positive diarrhea groups, than in the CD negative group. A linear discriminant analysis model based on capsiamide, dihydrosphingosine, and glycochenodeoxycholic acid was further constructed to identify CD infection in diarrhea. The leave-one-out cross-validation accuracy and area under receiver operating characteristic curve for the training set/external validation set were 90.00/78.57%, and 0.900/0.7917 respectively.
conclusionsCompared with other hospital-onset diarrhea, CD diarrhea has distinct fecal metabolome characteristics. Our UPLC-MS metabolomics model might be useful tool for diagnosing CD diarrhea.
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