ArticleMetabolomics : Official journal of the Metabolomic Society2018
Urine metabolites are associated with glomerular lesions in type 2 diabetes.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2023Trial
- Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.Metabolomics : Official journal of the Metabolomic Society · 2021Trial
- Fecal Microbiome and Urine Metabolome Profiling of Type 2 Diabetes.Journal of microbiology and biotechnology · 2025Article
- The Potential Use of Targeted Proteomics and Metabolomics for the Identification and Monitoring of Diabetic Kidney Disease.Journal of personalized medicine · 2024Review
- Metabolomics in diabetic nephropathy: Unveiling novel biomarkers for diagnosis (Review).Molecular medicine reports · 2024Review
- Gut microbiota and metabolic profiles in adults with unclassified diabetes: a cross-sectional study.Frontiers in endocrinology · 2024Article
- The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice.International journal of molecular sciences · 2023Article
- Urine-Based Detection of Biomarkers Indicative of Chronic Kidney Disease in a Patient Cohort from Ghana.Journal of personalized medicine · 2022Article
- Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration.Scientific reports · 2021Article
- Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease.Frontiers in endocrinology · 2021Article
- Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan.International journal of molecular sciences · 2020Article
- Urine Metabolomics Analysis in Patients With Normoalbuminuric Diabetic Kidney Disease.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionLittle is known about the association of urine metabolites with structural lesions in persons with diabetes.
objectivesWe examined the relationship between 12 urine metabolites and kidney structure in American Indians with type 2 diabetes.
methodsData were from a 6-year clinical trial that assessed renoprotective efficacy of losartan, and included a kidney biopsy at the end of the treatment period. Metabolites were measured in urine samples collected within a median of 6.5 months before the research biopsy. Associations of the creatinine-adjusted urine metabolites with kidney structural variables were examined by Pearson's correlations and multivariable linear regression after adjustment for age, sex, diabetes duration, hemoglobin A
resultsParticipants (n = 62, mean age 45 ± 10 years) had mean ± standard deviation glomerular filtration rate of 137 ± 50 ml/min and median (interquartile range) urine albumin:creatinine ratio of 34 (14-85) mg/g near the time of the biopsy. Urine aconitic and glycolic acids correlated positively with glomerular filtration surface density (partial r = 0.29, P = 0.030 and r = 0.50, P < 0.001) and total filtration surface per glomerulus (partial r = 0.32, P = 0.019 and r = 0.43, P = 0.001). 2-ethyl 3-OH propionate correlated positively with the percentage of fenestrated endothelium (partial r = 0.32, P = 0.019). Citric acid correlated negatively with mesangial fractional volume (partial r=-0.36, P = 0.007), and homovanillic acid correlated negatively with podocyte foot process width (partial r=-0.31, P = 0.022).
conclusionsAlterations of urine metabolites may associate with early glomerular lesions in diabetic kidney disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.