ArticleMetabolomics : Official journal of the Metabolomic Society2018
Overexpression of AtWRKY50 is correlated with enhanced production of sinapic derivatives in Arabidopsis.
Article in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 25 citations in OpenAlex.
- Sinapoylglucose: malate sinapoyltransferase SNG1 negatively regulates drought resistance by crosstalk with abscisic acid signaling in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Mechanisms of Exogenous Brassinosteroids and Abscisic Acid in Regulating Maize Cold Stress Tolerance.International journal of molecular sciences · 2025Article
- Identification of CAP genes in finger lime (Citrus australasica) and their role in plant responses to abiotic and biotic stress.Scientific reports · 2024Article
- Genome-wide identification, expression analysis of WRKY transcription factors in Citrus ichangensis and functional validation of CiWRKY31 in response to cold stress.BMC plant biology · 2024Article
- NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches.Molecules (Basel, Switzerland) · 2023Article
- Expression and Functional Study ofFrontiers in plant science · 2022Article
- Unusual DNA-binding properties of the Arabidopsis thaliana WRKY50 transcription factor at target gene promoters.Plant cell reports · 2021Article
- Genome-wide identification and functional characterization of the Camelina sativa WRKY gene family in response to abiotic stress.BMC genomics · 2020Article
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5 authors at 1 institution in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
introductionWRKY proteins belong to a plant-specific class of transcription factors. Seventy-four WKRY genes have been identified in Arabidopsis and many WRKY proteins are known to be involved in responses to stress, especially to biotic stress. They may act either as transcriptional activators or as repressors of genes that play roles in the stress response. A number of studies have proposed the connection of Arabidopsis WRKY transcription factors in induced pathogenesis-related (PR) gene expression, although no direct evidence has been presented for specific WRKY-PR promoter interactions.
objectiveWe previously identified AtWRKY50 as a transcriptional activator of SAR gene PR1. Although PR1 accumulates to high levels in plants after attack by pathogens, its function is still elusive. Here we investigated the effects of overexpression of several WRKY proteins, including AtWRKY50, on the metabolome of Arabidopsis thaliana.
methodsThe influence of overexpression of WRKY proteins on the metabolites of Arabidopsis was investigated by using an NMR spectroscopy-based metabolomic approach. The
resultsThe results showed that the metabolome of transgenic Arabidopsis seedlings overexpressing AtWRKY50 was different from wild type Arabidopsis and transgenic Arabidopsis overexpressing other WRKY genes. Amongst other metabolites, sinapic acid and 1-O-sinapoyl-β-D-glucose especially appeared to be the most prominent discriminating metabolites, accumulating to levels 2 to 3 times higher in the AtWRKY50 overexpressor lines.
conclusionOur results indicate a possible involvement of AtWRKY50 in secondary metabolite production in Arabidopsis, in particular of hydroxycinnamates such as sinapic acid and 1-O-sinapoyl-β-D-glucose.
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