Evidence map›Paper›PMID 30830334›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2017

Distinct differences in serum eicosanoids in healthy, enteritis and colorectal cancer individuals.

Junjie Zhang, Qingjin Yang, Jian Li, Yu Zhong, Lijian Zhang, Qionglin Huang, Bin Chen, Mingming Mo, Sensen Shen, Qisheng Zhong and 2 more

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Junjie ZhangAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Qingjin YangAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Jian LiAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Yu ZhongAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Lijian ZhangAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Qionglin HuangAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Bin ChenAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Mingming MoAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.
Sensen ShenBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering Peking University, Beijing, 100871, China.
Qisheng ZhongShimadzu Global COE for Application and Technical Development, Guangzhou, Guangdong, 510010, China.
Huwei LiuBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering Peking University, Beijing, 100871, China.
Chun CaiAnalysis Center, Zhanjiang Scientific Center of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China. caichun2006@tom.com.
Guangdong Medical College · CNBeijing National Laboratory for Molecular Sciences · CNPeking University · CNShimadzu (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEicosanoids as inflammatory mediators take part in the regulation of disease progression. However, the application of serum eicosanoid in disease progression identification was still uncertain.

methodsSerum from 52 healthy volunteers, 34 enteritis patients and 55 colorectal cancer (CRC) patients were collected. Ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used to analyze the change of serum eicosanoids.

resultsOf 158 eicosanoids, we found that lower levels of anti-inflammatory eicosanoids 13-HOTrE, 9-HOTrE, DHA, 11-HETE and 12-HHT were observed in enteritis and CRC group compared with healthy group, meanwhile the content of 5-iPF2α-VI as oxidative stress mediator in enteritis and CRC group was greater than that in healthy groups. Moreover, 9-HODE, 13-HODE, 12,13-diHOME, 8-HETE and 15-HETE were dramatically decrease in CRC group compared with non-CRC group. Additionally, the change of 5-, 12- and 15-HETE content in serum sample was associated with progression from healthy to enteritis, finally to CRC. No significant difference between serum eicosanoids and the expression of CerbB-2 and Ki67 were observed.

conclusionSerum eicosanoids might be used as a possible biomarker for identifying among health, enteritis and CRC.

Indexed as

AgedBiomarkersChromatography, High Pressure LiquidColorectal NeoplasmsEicosanoidsEnteritisFatty Acids, UnsaturatedFemaleHumansHydroxyeicosatetraenoic AcidsMaleMetabolic Networks and PathwaysMiddle AgedMultivariate AnalysisOxidative StressTandem Mass SpectrometryBiomarkersEicosanoidsFatty Acids, UnsaturatedHydroxyeicosatetraenoic Acidsoctadecadienoic acidColorectal cancerEicosanoidsEnteritisHealthUPLC-MS/MS

Identifiers

PMID30830334
OpenAlexW2770953523

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.