ReviewMetabolomics : Official journal of the Metabolomic Society2018
Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test.
Review in Metabolomics : Official journal of the Metabolomic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
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- Exometabolome variation in the fungal pathogen of humansApplied and environmental microbiology · 2026Article
- NMR Based Real-Time Analysis of Exometabolites Decodes the Mechanism of Action of Antibacterial Molecules, Nanoparticles, and Materials.Analytical chemistry · 2026Article
- Dual effects of vaginal Candida albicans on human papillomavirus infection: A large-scale multicenter study in Chinese women.Journal of advanced research · 2026Article
- Compounds Derived from Tryptophan Metabolism inInternational journal of molecular sciences · 2025Article
- Novel anaerobic selenium oxyanion reducers native to FGD wastewater for enhanced selenium removal.Applied and environmental microbiology · 2025Article
- Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition.The ISME journal · 2025Article
- Article
- Antifungal Activity of Disalt of Epipyrone A fromJournal of fungi (Basel, Switzerland) · 2024Article
- Bacterial adenine cross-feeding stems from a purine salvage bottleneck.The ISME journal · 2024Article
- Bacterial protein acetylation: mechanisms, functions, and methods for study.Frontiers in cellular and infection microbiology · 2024Review
- Predicting bacterial interaction outcomes from monoculture growth and supernatant assays.ISME communications · 2024Article
- A purine salvage bottleneck leads to bacterial adenine cross-feeding.bioRxiv : the preprint server for biology · 2023Article
- Asparagine Uptake: a Cellular Strategy ofApplied and environmental microbiology · 2023Article
- Osmotically Activated Anion Current of Phycomyces Blakesleeanus-Filamentous Fungi Counterpart to Vertebrate Volume Regulated Anion Current.Journal of fungi (Basel, Switzerland) · 2023Article
- Production, characterization and techno-economic evaluation of Aspergillus fusant L-asparaginase.AMB Express · 2023Article
- More than Meets the Eye: Untargeted Metabolomics and Lipidomics Reveal Complex Pathways Spurred by Activation of Acid Resistance Mechanisms inJournal of proteome research · 2022Article
- Control of redox potential in a novel continuous bioelectrochemical system led to remarkable metabolic and energetic responses of Clostridium pasteurianum grown on glycerol.Microbial cell factories · 2022Article
- Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms.mSystems · 2022Article
- Initial community composition determines the long-term dynamics of a microbial cross-feeding interaction by modulating niche availability.ISME communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMicrobial cells secrete many metabolites during growth, including important intermediates of the central carbon metabolism. This has not been taken into account by researchers when modeling microbial metabolism for metabolic engineering and systems biology studies. MATERIALS AND
methodsThe uptake of metabolites by microorganisms is well studied, but our knowledge of how and why they secrete different intracellular compounds is poor. The secretion of metabolites by microbial cells has traditionally been regarded as a consequence of intracellular metabolic overflow.
conclusionsHere, we provide evidence based on time-series metabolomics data that microbial cells eliminate some metabolites in response to environmental cues, independent of metabolic overflow. Moreover, we review the different mechanisms of metabolite secretion and explore how this knowledge can benefit metabolic modeling and engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.