ArticleMetabolomics : Official journal of the Metabolomic Society2017
Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.
Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing.Journal of cellular and molecular medicine · 2026Article
- Mapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile, and vascular dysfunction.Cell reports. Medicine · 2025Article
- NADJournal of neuroinflammation · 2025Article
- A mixed-mode LC-MS-based method for comprehensive analysis of NAD and related metabolites from biological sample matrices.Scientific reports · 2025Article
- Zic-HILIC MS/MS Method for NADomics Provides Novel Insights into Redox Homeostasis inMetabolites · 2024Article
- Fertility protection during chemotherapy treatment by boosting the NAD(P)EMBO molecular medicine · 2024Article
- A Simple, Fast, Sensitive LC-MS/MS Method to Quantify NAD(H) in Biological Samples: Plasma NAD(H) Measurement to Monitor Brain Pathophysiology.International journal of molecular sciences · 2024Article
- Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations.The Biochemical journal · 2023Article
- Metabolic Alterations in NADSYN1-Deficient Cells.Metabolites · 2023Article
- Fingerstick blood assay maps real-world NADAging cell · 2023Article
- A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples.Frontiers in immunology · 2023Article
- NADThe Journal of reproduction and development · 2022Review
- Tryptophan Metabolism 'Hub' Gene Expression Associates with Increased Inflammation and Severe Disease Outcomes in COVID-19 Infection and Inflammatory Bowel Disease.International journal of molecular sciences · 2022Article
- Declining muscle NADMolecular metabolism · 2022Article
- Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol.Pharmacology research & perspectives · 2022Article
- Supplemental Nicotinic Acid Elevates NADAnimals : an open access journal from MDPI · 2022Article
- Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Article
- Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS.Journal of neurochemistry · 2021Article
- A Method to Monitor the NADInternational journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionNicotinamide adenine dinucleotide (NAD
objectivesA study was performed to develop a sensitive, selective, robust, reproducible, and rapid method for the concurrent quantitative determination of intracellular levels of the NAD
methodsThe metabolites were separated on a versatile amino column using a dual HILIC-RP gradient with heated electrospray (HESI) tandem mass spectrometry detection in mixed polarity multiple reaction monitoring mode.
resultsQuantification of 17 metabolites in the NAD
conclusionThis method can be used as a sensitive profiling tool, tailoring chromatography for metabolites that express significant pathophysiological changes in several disease conditions and is indispensable for targeted analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.