Evidence map›Paper›PMID 30830277›Full record

ReviewEuropean journal of applied physiology2019

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state.

Katarzyna Patrycja Dzik, Jan Jacek Kaczor

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04768023 (Influence of 12 Weeks Vitamin D Supplementation Combined With Physical Activity on Blood and Functional Parameters and Quality of Life in Parkinson's Disease Patients Treated With Deep Brain Stimulation), which is not on this map. Cited by 184 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 15 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04768023 nacompletednot on this map

Influence of 12 Weeks Vitamin D Supplementation Combined With Physical Activity on Blood and Functional Parameters and Quality of Life in Parkinson's Disease Patients Treated With Deep Brain Stimulation

TypeinterventionalSponsorMedical University of GdanskRan2019 to 2022Enrolled50ConditionsVitamin D Deficiency, Parkinson DiseaseArmsJuvit D3, Placebo
3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 15 syntheses or guidelines pooled it, 336 citations in OpenAlex.

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  10. Association Between Vitamin D Supplementation and Statin-Associated Muscle Symptoms: A Systematic Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
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  15. Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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  16. Eight-Week Vitamin DNutrients · 2026
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  20. Effect of vitamin DJournal of the International Society of Sports Nutrition · 2023
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katarzyna Patrycja DzikDepartment of Neurobiology of Muscle, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336, Gdansk, Poland.
Jan Jacek KaczorDepartment of Neurobiology of Muscle, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336, Gdansk, Poland. jacek.kaczor@awf.gda.pl.ORCID http://orcid.org/0000-0002-6370-2160
Gdansk University of Physical Education and Sport · PL

Funding

Narodowe Centrum Nauki NCN UMO-2012/05/B/NZ7/02493
6 · The paper itself

Abstract

purposeThis review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism. It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.

methodThe interaction between vitamin D deficiency and mitochondrial function as well as skeletal muscle atrophy signalling pathways have been studied and clarified in the last years. To the best of our knowledge, we summarize key knowledge and knowledge gaps regarding the mechanism(s) of action of vitamin D in skeletal muscle.

resultVitamin D deficiency is associated with oxidative stress in skeletal muscle that influences the mitochondrial function and affects the development of skeletal muscle atrophy. Namely, vitamin D deficiency decreases oxygen consumption rate and induces disruption of mitochondrial function. These deleterious consequences on muscle may be associated through the vitamin D receptor (VDR) action. Moreover, vitamin D deficiency may contribute to the development of muscle atrophy. The possible signalling pathway triggering the expression of Atrogin-1 involves Src-ERK1/2-Akt- FOXO causing protein degradation.

conclusionBased on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.

Indexed as

AnimalsEnergy MetabolismHumansMitochondriaMuscle, SkeletalOxidative StressVitamin DVitamin D DeficiencyVitamin DMitochondriaMuscle atrophySkeletal muscleVitamin DVitamin D receptor

Identifiers

PMID30830277
PMCPMC6422984
OpenAlexW2919190158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.