ArticleWorld journal of surgery2019
Treatment Strategies and Survival Trends for Anorectal Melanoma: Is it Time for a Change?
Article in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Pooled it
- Insurance, race, and socioeconomic disparities in systemic therapy receipt for melanoma in the United States: a systematic review.Melanoma management · 2026Review
- Multidisciplinary Management of Anorectal Melanoma: a Retrospective Analysis of Surgical and Systemic Therapies from the National Cancer Database.Journal of gastrointestinal cancer · 2025Article
- A 22-year experience of surgical management of anorectal melanoma: risk factors for recurrence and death.International journal of colorectal disease · 2025Observational
- Article
- Efficacy of immune checkpoint inhibitors in patients with anorectal melanoma in association with immune-related adverse events: a case series.Clinical journal of gastroenterology · 2023Article
- Primary anorectal melanoma mimicking polyp in a scleroderma patient: a case report.Annals of medicine and surgery (2012) · 2023Article
- Treatment outcomes and prognostic factors in 47 patients with primary anorectal malignant melanoma in the immune therapy era.Journal of cancer research and clinical oncology · 2023Article
- Organ preservation in anorectal melanoma: A tempting challenge-a case report.SAGE open medical case reports · 2023Article
- BRAF, NRAS, KIT, TERT, GNAQ/GNA11 Mutation Profile and Histomorphological Analysis of Anorectal Melanomas: A Clinicopathologic Study.Turk patoloji dergisi · 2023Article
- Article
- Can transrectal ultrasonography distinguish anorectal malignant melanoma from low rectal adenocarcinoma? A retrospective paired study for ten years.BMC gastroenterology · 2022Article
- A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma.Dermatology reports · 2021Article
- Anorectal Amelanotic Melanoma.GE Portuguese journal of gastroenterology · 2021Article
- Anorectal Mucosal Melanoma in the Era of Immune Checkpoint Inhibition: Should We Change Our Surgical Management Paradigm?Diseases of the colon and rectum · 2021Article
- Anorectal Melanoma Misdiagnosed as Hemorrhoids: A Case Report and Review of the Literature.The Journal of clinical and aesthetic dermatology · 2021Article
- Trends in the management of anorectal melanoma: A multi-institutional retrospective study and review of the world literature.World journal of gastroenterology · 2021Article
- Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- A Rare Case of Primary Anorectal Melanoma and a Review of the Current Landscape of Therapy.Journal of community hospital internal medicine perspectives · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunotherapy advances for the treatment of cutaneous melanoma question its efficacy in treating anorectal mucosal melanoma (ARMM). We aimed to identify the prevalence, current management, and overall survival (OS) for ARMM.
methodsReview of patients with ARMM from 2004 to 2015 National Cancer Database. Factors associated with immunotherapy were identified using multivariable logistic regression. The primary outcome was 2- and 5-year OS. Subgroup analysis by treatment type was performed.
resultsA total of 1331 patients were identified with a significant increase in prevalence (2004: 6.99%, 2015: 10.53%). ARMM patients were older, white, on Medicare, and from the South. The most common treatment was surgery (48.77%), followed by surgery + radiation (11.75%), surgery + immunotherapy (8.68%), and surgery + chemotherapy (8.68%). 16.93% of patients received immunotherapy, with utilization increasing (7.24%: 2004, 21.27%: 2015, p < 0.001). Patients who received immunotherapy had a significantly better 2-year OS (42.47% vs. 49.21%, p < 0.001), and other therapies did not reveal a significant difference. Adjusted analysis showed no difference in 2- and 5-year OS based on therapy type.
conclusionThe prevalence of ARMM has increased. The use of immunotherapy has increased substantially. Some survival benefit with the administration of immunotherapy may exist that has yet to be revealed. A more aggressive treatment paradigm is warranted.
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