ArticleGenome biology and evolution2019
Insights into the Genomics of Clownfish Adaptive Radiation: Genetic Basis of the Mutualism with Sea Anemones.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Stable yet shifting: Early toxin dynamics in typical and atypical clownfish-anemone symbioses.Toxicon: X · 2026Article
- Molecular Drivers of Mutualistic Association Between Anemone and Anemonefish.Genome biology and evolution · 2026Article
- Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The First De Novo HiFi Genome Assemblies for Three Clownfish-hosting Sea Anemone Species (Anthozoa: Actiniaria).Genome biology and evolution · 2025Article
- Host use drives convergent evolution in clownfish.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic Architecture of the Clownfish Hybrid Amphiprion leucokranos.Genome biology and evolution · 2025Article
- Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging.BMC biology · 2025Article
- N-acetylated sugars in clownfish and damselfish skin mucus as messengers involved in chemical recognition by anemone host.Scientific reports · 2025Article
- Article
- The genome of the sapphire damselfishGigaByte (Hong Kong, China) · 2024Article
- Insights into the Genomics of Clownfish Adaptive Radiation: The Genomic Substrate of the Diversification.Genome biology and evolution · 2023Article
- Chromosome-level genome of the three-spot damselfish, Dascyllus trimaculatus.G3 (Bethesda, Md.) · 2023Article
- The chromosome-scale genome assembly of the yellowtail clownfish Amphiprion clarkii provides insights into the melanic pigmentation of anemonefish.G3 (Bethesda, Md.) · 2023Article
- Anemonefishes: A model system for evolutionary genomics.F1000Research · 2023Review
- Never, Ever Make an Enemy… Out of an Anemone: Transcriptomic Comparison of Clownfish Hosting Sea Anemone Venoms.Marine drugs · 2022Review
- A chromosome-scale genome assembly of the false clownfish, Amphiprion ocellaris.G3 (Bethesda, Md.) · 2022Article
- The real Nemo movie: Description of embryonic development in Amphiprion ocellaris from first division to hatching.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Molecular Evolution of Ultraviolet Visual Opsins and Spectral Tuning of Photoreceptors in Anemonefishes (Amphiprioninae).Genome biology and evolution · 2021Article
- Molecular Evolution of Ecological Specialisation: Genomic Insights from the Diversification of Murine Rodents.Genome biology and evolution · 2021Article
- A Cautionary Note on the Use of Genotype Callers in Phylogenomics.Systematic biology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clownfishes are an iconic group of coral reef fishes, especially known for their mutualism with sea anemones. This mutualism is particularly interesting as it likely acted as the key innovation that triggered clownfish adaptive radiation. Indeed, after the acquisition of the mutualism, clownfishes diversified into multiple ecological niches linked with host and habitat use. However, despite the importance of this mutualism, the genetic mechanisms allowing clownfishes to interact with sea anemones are still unclear. Here, we used a comparative genomics and molecular evolutionary analyses to investigate the genetic basis of clownfish mutualism with sea anemones. We assembled and annotated the genome of nine clownfish species and one closely related outgroup. Orthologous genes inferred between these species and additional publicly available teleost genomes resulted in almost 16,000 genes that were tested for positively selected substitutions potentially involved in the adaptation of clownfishes to live in sea anemones. We identified 17 genes with a signal of positive selection at the origin of clownfish radiation. Two of them (Versican core protein and Protein O-GlcNAse) show particularly interesting functions associated with N-acetylated sugars, which are known to be involved in sea anemone discharge of toxins. This study provides the first insights into the genetic mechanisms of clownfish mutualism with sea anemones. Indeed, we identified the first candidate genes likely to be associated with clownfish protection form sea anemones, and thus the evolution of their mutualism. Additionally, the genomic resources acquired represent a valuable resource for further investigation of the genomic basis of clownfish adaptive radiation.
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