ReviewActa bio-medica : Atenei Parmensis2019
Hypersensitivity reactions to food and drug additives: problem or myth?
Review in Acta bio-medica : Atenei Parmensis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the safety of oral methylene blue during swallowing assessment: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Pooled it
- Pediatrics advances in 2024: choices in allergy, cardiology, critical care, endocrinology, gastroenterology, immunology, infectious diseases, neonatology, nephrology, neurology, nutrition, palliative care respiratory tract illnesses, and social media.Italian journal of pediatrics · 2025Review
- A comprehensive landscape of AI applications in broad-spectrum drug interaction prediction: a systematic review.Journal of cheminformatics · 2025Review
- A survey of current management practices for delayed maculopapular exanthemas during antibiotic treatment among primary care pediatricians.Italian journal of pediatrics · 2025Article
- Potential Role of Dietary Antioxidants During Skin Aging.Food science & nutrition · 2025Review
- Review
- The unseen animal behind medicine: exploring considerations of animal-derived medications and anaesthetics in today's landscape.BJA open · 2025Review
- Case Report: Not all recurrent "idiopathic" anaphylaxis is idiopathic.Frontiers in allergy · 2025Article
- Microbial conversion of vegetable waste for flavor additives via solid-state fermentation: a comprehensive review.Frontiers in nutrition · 2025Review
- A survey on prevalence and parents' perceptions of food allergy in 3- to 16-year-old children in Wuhan, China.The World Allergy Organization journal · 2024Article
- Rare causes of pediatric anaphylaxis due to obscure allergens.Frontiers in allergy · 2024Review
- Inhibition Mechanism of Chitooligosaccharide-Polyphenol Conjugates toward Polyphenoloxidase from Shrimp Cephalothorax.Molecules (Basel, Switzerland) · 2023Article
- Dyes Used in Processed Meat Products in the Polish Market, and Their Possible Risks and Benefits for Consumer Health.Foods (Basel, Switzerland) · 2023Article
- Hidden and Rare Food Allergens in Pediatric Age.Nutrients · 2023Review
- A Case Report of Allergic Hypersensitivity to Color Additives in Slurpee® Beverages.The Yale journal of biology and medicine · 2023Review
- Management of Adult Patients with Gastrointestinal Symptoms from Food Hypersensitivity-Narrative Review.Journal of clinical medicine · 2022Review
- Additives in Children's Nutrition-A Review of Current Events.International journal of environmental research and public health · 2022Review
- Hypersensitivity Reactions to Food Additives-Preservatives, Antioxidants, Flavor Enhancers.International journal of environmental research and public health · 2022Review
- Current perspective on veterinary drug and chemical residues in food of animal origin.Environmental science and pollution research international · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and aim of the workThe possibility of an allergic reaction or an intolerance to additives is frequently suspected by parents, especially for chronic illness with frequent exacerbations such as atopic dermatitis or chronic urticaria. For more than 50 years, potential adverse reactions to additives have been suggested, but to date data are conflicting. The purpose of this article is to provide the clinicians with general information about additives and adverse reactions to them and to suggest a practical approach to children suspected to have reactions to food additives.
methodsWe performed an extensive research on all English-language Medline articles, case reports and reviews published online until December 2018. Used search terms were: food additives, food dye, adverse reactions, food allergy, food hypersensitivity, intolerance, drugs, children.
resultsThere are only few case reports of adverse reactions in childhood with a clear involvement of additives. In this review article we reported the associations between additives and adverse reactions described in literature, in order to inform the pediatrician about the potential clinical manifestations.
conclusionsPrior to suspect an adverse reaction to additives, it is important to rule out other possible causes: the diagnostic process is complicated and rarely conclusive. The gold standard is the double-blind placebo controlled oral challenge after an exclusion diet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.