Evidence map›Paper›PMID 30830061›Full record

ReviewActa bio-medica : Atenei Parmensis2019

Mechanisms of hypersensitivity reactions induced by drugs.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli

Open access · greenAbstract readReview
In one paragraph

Review in Acta bio-medica : Atenei Parmensis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ex vivo Drug Metabolism Using Primary Human Hepatocytes for the Detection of Metabolite-Dependent Antibodies to Red Blood Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Eosinophilia associated with nintedanib therapy.Respiratory medicine case reports · 2025
    Article
  10. Article
  11. Article
  12. Whole-Blood 3-Gene Signature as a Decision Aid for Rifapentine-based Tuberculosis Preventive Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Fabrizio FranceschiniUOC Pediatria, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", Ancona, Italy. allped@libero.it.
Paolo Bottau
Silvia Caimmi
Fabio Cardinale
Giuseppe Crisafulli
Lucia Liotti
Francesca Saretta
Roberto Bernardini
Francesca Mori
Carlo Caffarelli
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITMeyer Children's Hospital · ITOspedale San Giuseppe · ITPoliclinico San Matteo Fondazione · ITUniversity of Messina · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.

Indexed as

Drug HypersensitivityHumansPhenotype

Identifiers

PMID30830061
PMCPMC6502177
OpenAlexW2988358600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.