Trial reportDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2019
Collagenase Clostridium Histolyticum for the Treatment of Edematous Fibrosclerotic Panniculopathy (Cellulite): A Randomized Trial.
Trial report in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.Aesthetic plastic surgery · 2025Pooled it
- Evaluation of five collagenase clostridium histolyticum-aaes injection techniques for the treatment of cellulite on the buttock or thigh.Journal of cosmetic dermatology · 2022Trial
- High-Frequency Ultrasound Imaging for Stage III Cellulite: A Three-Subtype Structural Classification from an Observational Cohort Study.Dermatology and therapy · 2025Article
- Comparing Collagenase and Tissue Subcision for Cellulite Treatment of the Buttock and Thigh Regions: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Square technique-A treatment for cellulite with large size particle hyaluronic acid.Skin health and disease · 2024Article
- Real-World Experience With Collagenase Clostridium Histolyticum-aaes for Buttock and Thigh Cellulite: Focus on Administration and Safety Profile.Aesthetic surgery journal. Open forum · 2023Article
- Cellulite: Current Understanding and Treatment.Aesthetic surgery journal. Open forum · 2023Review
- Characterization of Tissue Histology for the Injectable Cellulite Treatment Collagenase Clostridium Histolyticum-aaes: Results in Swine.Aesthetic surgery journal. Open forum · 2023Article
- Collagenase Clostridium Histolyticum-aaes for Treatment of Cellulite: A Pooled Analysis of Two Phase-3 Trials.Plastic and reconstructive surgery. Global open · 2022Article
- CollagenaseAesthetic surgery journal. Open forum · 2022Article
- Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial.Lasers in surgery and medicine · 2022Article
- Evaluation of alternative diluents for clinical use of collagenase clostridium histolyticum (CCH-aaes).Journal of cosmetic dermatology · 2021Article
- Comparison of Cellulite Severity Scales and Imaging Methods.Aesthetic surgery journal · 2021Article
- Efficacy, Safety, and Durability of Response of Collagenase Clostridium Histolyticum-aaes for Treating Cellulite.Plastic and reconstructive surgery. Global open · 2020Article
- Development and Validation Clinician and Patient Reported Photonumeric Scales to Assess Buttocks Cellulite Severity.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020Article
- Insights Into the Pathophysiology of Cellulite: A Review.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEdematous fibrosclerotic panniculopathy (EFP; cellulite) is associated with thickening and contraction of collagen-rich subdermal septae. Collagenase clostridium histolyticum (CCH) may disrupt collagen-rich septae.
objectiveTo evaluate the safety and efficacy of CCH for treatment of EFP. MATERIALS AND
methodsIn a randomized, double-blind study, women with moderate or severe EFP of the buttocks or posterolateral thighs (i.e., Clinician Reported Photonumeric Cellulite Severity Scale [CR-PCSS] and Patient Reported Photonumeric Cellulite Severity Scale [PR-PCSS] ratings of 3 to 4, and Hexsel Cellulite Severity Scale score ≤13) received up to 3 treatment sessions (Days 1, 22, and 43) of subcutaneous CCH 0.84 mg or placebo injections. End points included the percentage of 2-level and 1-level composite responders (i.e., had ≥2-level or ≥1-level improvement in CR-PCSS and PR-PCSS) at Day 71.
resultsThree hundred seventy-five women (mean age, 46.5 years; 86.4% white) were randomly assigned to CCH (n = 189) or placebo (n = 186). At Day 71, the percentages of 2-level and 1-level composite responders were greater with CCH (10.6% and 44.6%, respectively) versus placebo (1.6% and 17.9%; p < .001 for both). The most common adverse events were injection-site related.
conclusionCCH significantly improved EFP appearance versus placebo; further evaluation of CCH for EFP (cellulite) is warranted.
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