ArticleCancer biomarkers : section A of Disease markers2019
Elevated platelet distribution width predicts poor prognosis in hepatocellular carcinoma.
Article in Cancer biomarkers : section A of Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic and clinicopathological significance of pretreatment mean platelet volume in cancer: a meta-analysis.BMJ open · 2020Pooled it
- Predicting the prognosis of hepatocellular carcinoma after curative resection using a nomogram based on the ratio of prealbumin to platelet distribution width.Journal of gastrointestinal oncology · 2025Article
- Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Causal Analysis of Platelet Indices and Breast Cancer, Including Estrogen Receptor-Specific Subtypes: A Mendelian Randomization Study.International journal of women's health · 2025Article
- Construction of a combined prognostic model for pancreatic ductal adenocarcinoma based on deep learning and digital pathology images.BMC gastroenterology · 2024Article
- Prognostic value of combined preoperative inflammatory marker neutrophil-lymphocyte ratio and platelet distribution width in patients with gallbladder carcinoma.Langenbeck's archives of surgery · 2024Article
- Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy.BMC cancer · 2023Article
- Increased Platelet Distribution Width Predicts 3-Year Recurrence in Patients with Hepatocellular Carcinoma After Surgical Resection.Cancer management and research · 2023Article
- Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma.BMC cancer · 2022Article
- Preoperative platelet distribution width-to-platelet ratio combined with serum thyroglobulin may be objective and popularizable indicators in predicting papillary thyroid carcinoma.Journal of clinical laboratory analysis · 2022Article
- High platelet distribution width is an independent risk factor of postoperative pneumonia in patients with type A acute aortic dissection.Frontiers in cardiovascular medicine · 2022Article
- Prognostic significance of the combination of preoperative red cell distribution width and platelet distribution width in patients with gastric cancer.BMC cancer · 2021Article
- Prediction of late recurrence after radiofrequency ablation of HBV-related hepatocellular carcinoma with the age-male-albumin-bilirubin-platelets (aMAP) risk score: a multicenter study.Journal of gastrointestinal oncology · 2021Article
- [Overall survival and prognosis of patients with polycythemia vera: an analysis based on 906 patients from a single center].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021Article
- The Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in Predicting Response to Platinum-based Chemotherapy for Epithelial Ovarian Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Observational
- Development and validation of nomogram based on a novel platelet index score to predict prognosis in patients with renal cell carcinoma.Journal of Cancer · 2021Article
- Elevated Platelet Distribution Width Predicts Poor Prognosis in Gallbladder Carcinoma.Cancer management and research · 2021Article
- Article
- Evaluation of platelet distribution width as novel biomarker in gall bladder cancer.Journal of carcinogenesis · 2020Article
- Platelets in chronic liver disease, from bench to bedside.JHEP reports : innovation in hepatology · 2019Review
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6 authors.
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Abstract
backgroundPrevious studies have demonstrated that platelets play an important role in growth, invasion, and angiogenesis of a variety of tumors. Nevertheless, the prognostic role of platelet indices in hepatocellular carcinoma (HCC) has not been explored. The aim of this study was to explore the association between platelet indices and prognosis in HCC.
methodA total of 260 patients with HCC between January 2009 and December 2015 were retrospectively analyzed. The optimal platelet distribution width (PDW) cutoff value is identified by the receiver operating characteristic curve (ROC) curve. The relationship between PDW and clinicopathological features was assessed. The prognostic effects of PDW were assessed by using the Kaplan-Meier method and Cox regression model.
resultElevated PDW level was significantly associated with portal hypertension, vascular invasion, and Child-Pugh grade. In addition, survival curve indicates that patients with high PDW levels have a worse prognosis than patients with low PDW levels (P< 0.001). Multivariate Cox regression analysis identified PDW as an independent factor of prognosis in HCC patients (hazard ratio: 4.460, 95% confidence interval: 2.308-8.619, P< 0.001).
conclusionElevated PDW may be a novel marker for predicting the prognosis of HCC, but further research is needed to validate our conclusions.
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