ArticleeLife2019
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- L1 Cell Adhesion Molecule in Cancer, a Systematic Review on Domain-Specific Functions.International journal of molecular sciences · 2019Pooled it
- L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis.Nature communications · 2026Article
- STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4.Oncogene · 2026Article
- The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease.Cellular & molecular biology letters · 2025Review
- NOVA2 expression in pituitary gland and in functioning and non-functioning pituitary adenomas: a preliminary study.Acta neurochirurgica · 2025Article
- Blood-derived APLP1Science advances · 2025Article
- Harnessing brain-derived extracellular vesicles to support RDoC-based drug development.Neuroscience applied · 2025Review
- The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications.Cellular & molecular biology letters · 2024Review
- Prospects and challenges in using neuronal extracellular vesicles in biomarker research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Review
- Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs.Journal of extracellular vesicles · 2024Article
- Alternative splicing and related RNA binding proteins in human health and disease.Signal transduction and targeted therapy · 2024Review
- Circular RNA in Non-small Cell Lung Carcinoma: Identification of Targets and New Treatment Modalities.Cancer genomics & proteomics · 2023Review
- Identifying RNA Modifications by Direct RNA Sequencing Reveals Complexity of Epitranscriptomic Dynamics in Rice.Genomics, proteomics & bioinformatics · 2023Article
- Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges.Acta neuropathologica · 2023Review
- Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer.International journal of molecular sciences · 2023Article
- A review on comparative studies addressing exosome isolation methods from body fluids.Analytical and bioanalytical chemistry · 2023Review
- Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The emerging double-edged sword role of exosomes in Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
- Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression.EXCLI journal · 2023Review
Corrections and comments
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Authors and funding
27 authors at 13 institutions in 5 countries.
Francesca Angiolini *Unit of Gynecological Oncology Research, Program of Gynecological Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Elisa Belloni *Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.ORCID 0000-0001-6580-5553
Marco Giordano *Unit of Gynecological Oncology Research, Program of Gynecological Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0001-6335-0030
Matteo CampioniThe Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Federico FornerisThe Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.ORCID 0000-0002-7818-1804
Maria Paola ParonettoDepartment of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Rome, Italy.
Michela LupiaUnit of Gynecological Oncology Research, Program of Gynecological Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Chiara BrandasIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.
Davide PradellaIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.ORCID 0000-0002-8649-7817
Anna Di MatteoIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.
Costanza GiampietroFIRC Institute of Molecular Oncology, Milan, Italy.ORCID 0000-0001-5229-3835
Giovanna JodiceMolecular Medicine Program, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Chiara LuiseMolecular Medicine Program, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Giovanni BertalotMolecular Medicine Program, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0002-4862-7705
Stefano FreddiMolecular Medicine Program, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Matteo MalinvernoFIRC Institute of Molecular Oncology, Milan, Italy.
Manuel IrimiaCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jon D MoultonGene Tools LLC, Philomath, United States.ORCID 0000-0002-4977-0802
James SummertonGene Tools LLC, Philomath, United States.
Antonella ChiapparinoThe Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Carmen GhilardiLaboratory of Biology and Treatment of Metastasis, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Raffaella GiavazziLaboratory of Biology and Treatment of Metastasis, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Daniel NyqvistDivision of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Davide GabelliniDivision of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-3811-4121
Elisabetta DejanaFIRC Institute of Molecular Oncology, Milan, Italy.
Ugo Cavallaro *Unit of Gynecological Oncology Research, Program of Gynecological Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0002-0884-6460
Claudia Ghigna *Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.ORCID 0000-0003-0362-783X
European Institute of Oncology · ITIstituto di Genetica Molecolare · ITUniversity of Pavia · ITBrain Tools (United States) · USMario Negri Institute for Pharmacological Research · ITETH Zurich · CHForo Italico University of Rome · ITIFOM · ITInstitució Catalana de Recerca i Estudis Avançats · ESKarolinska Institutet · SEToscana Life Sciences · ITUppsala University · SEVita-Salute San Raffaele University · IT
Funding
Associazione Italiana per la Ricerca sul Cancro IG-14622Associazione Italiana per la Ricerca sul Cancro IG-17395Associazione Italiana per la Ricerca sul Cancro IG-18683Associazione Italiana per la Ricerca sul Cancro IG-18853Horizon 2020 Framework Programme ERC-StG-LS2-637591Ministerio de Economía y Competitividad BFU2017-89201-PWorldwide Cancer Research AICR 10-0091
Abstract
The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds directly to
Indexed as
Alternative SplicingAngiogenic ProteinsCells, CulturedEndothelial CellsHumansNerve Tissue ProteinsNeural Cell Adhesion Molecule L1Neuro-Oncological Ventral AntigenProtein IsoformsRNA-Binding ProteinsAngiogenic ProteinsL1CAM protein, humanNerve Tissue ProteinsNeural Cell Adhesion Molecule L1Neuro-Oncological Ventral AntigenNOVA2 protein, humanProtein IsoformsRNA-Binding ProteinsAngiogenesisatermative splicingcancer biologycell biologyhumanL1CAMmouseNOVA2Ovarian Cancer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.