Evidence map›Paper›PMID 30829460›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2019

Effects of a physical activity programme to prevent physical performance decline in onco-geriatric patients: a randomized multicentre trial.

Haritz Arrieta, Cyril Astrugue, Sophie Regueme, Jessica Durrieu, Aline Maillard, Alban Rieger, Eric Terrebonne, Christophe Laurent, Brigitte Maget, Véronique Servent and 5 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 11 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01432067 nacompletednot on this map

Physical Activity Advices to Prevent Loss of Autonomy in Cancer Treated Elderly Patients. An Intervention Randomized Study

TypeinterventionalSponsorUniversity Hospital, BordeauxRan2011 to 2016Enrolled302ConditionsCancer, Elderly PopulationArmsAdapted physical activity, Classic physical activities
NCT05915325 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Physical Training for Elderly Cancer Patients With Cachexia (TEECH-01): a Prospective Clinical Trial

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2023 to 2026Enrolled23ConditionsGeriatric Assessment, Cancer, Cancer CachexiaArmsPhysical training
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 11 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  9. Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Haritz ArrietaDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.ORCID 0000-0002-3912-6861
Cyril AstruguePole de Santé Publique, Service d'Information Médicale, Unité de Soutien Méthodologique à la Recherche Clinique et Epidémiologique, CHU de Bordeaux, Bordeaux, France.
Sophie ReguemePôle de gérontologie clinique, CHU de Bordeaux, Bordeaux, France.
Jessica DurrieuPôle de gérontologie clinique, CHU de Bordeaux, Bordeaux, France.
Aline MaillardPole de Santé Publique, Service d'Information Médicale, Unité de Soutien Méthodologique à la Recherche Clinique et Epidémiologique, CHU de Bordeaux, Bordeaux, France.
Alban RiegerPôle de gérontologie clinique, CHU de Bordeaux, Bordeaux, France.
Eric TerrebonnePôle appareil digestif, endocrinologie et nutrition, CHU de Bordeaux, Bordeaux, France.
Christophe LaurentPôle appareil digestif, endocrinologie et nutrition, CHU de Bordeaux, Bordeaux, France.
Brigitte MagetCLCC Reims, Institut Jean Godinot, Reims, France.
Véronique ServentCLCC Lille, Centre Oscar Lambret, Lille, France.
Sandrine Lavau-DenèsCHU de Limoges, Limoges Cedex, France.
Jérôme DaubaCH Mont de Marsan, Mont-de-Marsan, France.
Marianne FonckCLCC Bordeaux, Institut Bergonié, Bordeaux, France.
Rodolphe ThiébautPole de Santé Publique, Service d'Information Médicale, Unité de Soutien Méthodologique à la Recherche Clinique et Epidémiologique, CHU de Bordeaux, Bordeaux, France.
Isabelle Bourdel-MarchassonCNRS, RMSB, UMR 5536, Bordeaux, France.ORCID 0000-0002-6713-7832
Centre Hospitalier Universitaire de Bordeaux · FRCentre National de la Recherche Scientifique · FRCentre Hospitalier Universitaire de Limoges · FRCentre Oscar Lambret · FRInstitut Bergonié · FRInstitut Jean Godinot · FRNissan (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder adults with cancer experience negative long-term functional effects of both cancer and treatments. Exercise may minimize their age-related and cancer-related functional decline.

methodsWe conducted a multicentre open-label 12 month randomized clinical trial with two parallel arms including participants aged ≥70 years with lymphoma or carcinoma requiring curative treatment. The study started at the beginning of any phase of cancer treatment (surgery, chemotherapy, or radiotherapy). The usual care group (UCG) received the current national recommendations in physical activity (a guideline without specific counselling). The intervention group (IG) received 1 year phoned physical activity advice individually adapted to physical assessment (twice a month during the first 6 months and then monthly). The primary outcome was the proportion of subjects with a 1 year decreased short physical performance battery (SPPB) score of 1 point or more. Physical, cognitive, and clinical secondary outcomes were also investigated.

resultsWe allocated 301 participants (age 76.7 ± 5.0, female 60.6%) to each group. At baseline, the median SPPB was 10/12 in both groups. Breast was the most frequent tumour site (35.7%). After 1 year, 14.0% of participants in the UCG and 18.7% in the IG had a decrease in SPPB score of 1 point or more (P = 0.772). At 2 years, there was no difference in SPPB, gait speed, International Physical Activity Questionnaire score, and verbal fluency. Subgroup analyses after 2 years showed a decline in SPPB for 29.8% of UCG and 5.0% of IG breast cancer participants (P = 0.006), in 21.7% of UCG and 6.2% of IG female participants (P = 0.019), and in 24.5% of UCG and 11.1% of IG normal nutritional status participants (P = 0.009). Falls, hospitalization, institutionalization, and death rates were similar in both groups.

conclusionsPersonalized phoned physical activity advice had not reduced functional decline at 1 year but provided preliminary evidence that may prevent physical performance decline at 2 years in older adults with breast cancer.

Indexed as

ExerciseGeriatric AssessmentPhysical Functional PerformanceAccidental FallsAgedAged, 80 and overAge FactorsFemaleHospitalizationHumansIncidenceMaleNeoplasmsSocioeconomic FactorsAdapted physical activityBreast cancerFrailtyNutritionOnco-geriatrics

Identifiers

PMID30829460
PMCPMC6463460
OpenAlexW2919985383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.