Evidence map›Paper›PMID 30828884›Full record

ArticleMolecular carcinogenesis2019

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.

Alpna Tyagi, Sushil Kumar, Komal Raina, Michael F Wempe, Paul D Maroni, Rajesh Agarwal, Chapla Agarwal

Open access · greenAbstract read
In one paragraph

Article in Molecular carcinogenesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Alpna TyagiDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Sushil KumarDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Komal RainaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Michael F WempeDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Paul D MaroniUniversity of Colorado Cancer Center, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Rajesh AgarwalDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-9455-0235
Chapla AgarwalDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0003-1146-4890
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Cancer Center · USSouth Dakota State University · USUniversity of Colorado Hospital · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Skin Cancer Chemoprevention by Silibinin: Mechanisms and EfficacyR01CA140368 · NCI · UNIVERSITY OF COLORADO DENVER · PI AGARWAL, RAJESH · 2010 to 2021
$3.6M
Prostate Cancer Prevention by Procyanidins in Grape Seed ExtractR01CA091883 · NCI · UNIVERSITY OF COLORADO DENVER · PI AGARWAL, CHAPLA · 2003 to 2012
$3.3M
Molecular mechanism of bitter melon juice efficacy against pancreatic cancer.R01CA195708 · NCI · UNIVERSITY OF COLORADO DENVER · PI AGARWAL, RAJESH · 2014 to 2018
$2.2M
NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA091883NCI NIH HHS R01 CA140368NCI NIH HHS R01 CA195708
6 · The paper itself

Abstract

The present study aimed to determine whether grape seed extract (GSE) procyanidin mix, and its active constituent procyanidin B2 3,3″-di-O-gallate (B2G2) have the potential to target cancer stem cells (CSCs) in prostate cancer (PCa). The CSC populations were isolated and purified based on CD44

Indexed as

AnthocyaninsAntineoplastic Agents, PhytogenicApoptosisBiflavonoidsCatechinCell MovementCell ProliferationCell SurvivalGrape Seed ExtractHumansJagged-1 ProteinMaleNeoplastic Stem CellsPC-3 CellsProanthocyanidinsProstateAnthocyaninsAntineoplastic Agents, PhytogenicBiflavonoidsCatechinGrape Seed ExtractJagged-1 ProteinNOTCH1 protein, humanProanthocyanidinsprocyanidinprocyanidin B2-3,3'-di-O-gallateReceptor, Notch1chemopreventiongrape seed extractprocyanidin B2 3,3″-di-O-gallateprocyanidinsprostate cancerprostate cancer stem cells

Identifiers

PMID30828884
PMCPMC6548692
OpenAlexW2920664576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.