ArticleLaryngoscope investigative otolaryngology2019
Benign proliferative epithelial lesions of oral mucosa are infrequently associated with α-, β-, or γ human papillomaviruses.
Article in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Activation of Wnt/β-catenin signaling in histologically non-dysplastic non-homogeneous oral leukoplakia.BMC oral health · 2026Article
- Prevalence and Clinical Implications of HPV Infection in Oral Cavity and Oropharynx in HIV+ Men.International journal of dentistry · 2026Article
- Diagnostic challenges and clinical management gaps in HPV-related oral lesions.Frontiers in oral health · 2025Review
- Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature.Journal of immunology research · 2024Review
- Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review.Frontiers in public health · 2024Review
- Prevalence and Characteristics of Human Papillomavirus Infection in Oropharyngeal Squamous Cell Papilloma.Cancers · 2023Article
- Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas.PloS one · 2023Article
- Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity-An Update.Medicina (Kaunas, Lithuania) · 2022Review
- HPV-Associated Benign Squamous Cell Papillomas in the Upper Aero-Digestive Tract and Their Malignant Potential.Viruses · 2021Review
- Oral Infection by Mucosal and Cutaneous Human Papillomaviruses in the Men Who Have Sex with Men from the OHMAR Study.Viruses · 2020Article
- Role of human papillomavirus infection in the etiology of vulvar cancer in Italian women.Infectious agents and cancer · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundOral papillomas and verruca vulgaris have been associated with human papillomavirus (HPV) infection. However, approximately half of these have remained HPV-negative when tested for mucosal HPV genotypes. In this study, we evaluated presence of α-, β-, and γ-HPVs in benign papillary and verrucous lesions.
methodsEighty-three clinical lesions with suspected HPV etiology were analyzed for HPV types of genus α (n = 24), β (n = 46), and γ (n = 52). Immunohistochemistry was used for p16 as a possible surrogate marker of high-risk HPV, accompanied by Ki-67 proliferation marker.
resultsAltogether, α-HPVs were detected in 6.4%, β-HPVs in 2.4%, and γ-HPV in 4.8%. The following genotypes were identified: HPV6, 8, 11, 16, 22, 161, and 170. Neither Ki-67 nor p16 positivity alone were associated with HPV but combined staining showed significant inverse association (
conclusionHPV infection is found only in a minority of benign verrucous and papillary oral lesions, with the predominance of α-HPVs. LEVEL OF EVIDENCE: 4.
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